Local Injection of Allogeneic Stem Cells from Apical Papilla Enhanced Periodontal Tissue Regeneration in Minipig Model of Periodontitis

المؤلفون المشاركون

Li, Guoqing
Han, Nannan
Zhang, Xiuli
Yang, Haoqing
Cao, Yangyang
Wang, Songlin
Fan, Zhipeng

المصدر

BioMed Research International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-07-12

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

Discovering suitable seeding cells and simple application technique will be beneficial for MSC-mediated treatment of periodontitis.

Stem cells from apical papilla (SCAPs) might be the candidate seeding cell for the periodontal tissues regeneration based on their origin and characters.

In this research, we investigated the effect of SCAPs on periodontal tissue regeneration in swine by local injection.

Methods.

We established experimental periodontitis model in miniature pigs and then treated them with SCAPs by local injection.

Clinical assessments, computed tomography (CT) scanning, histologic examination, and quantitative measurements were used to evaluate the effect of periodontal tissues regeneration.

Results.

At 12 weeks after injection, clinical assessments showed that probing depth, gingival recession, and attachment loss values were 5.44±0.77 mm versus 7.33±1.0 mm (p<0.01), 2.33±0.33 mm versus 2.11±0.69 mm (p>0.05), and 7.78±0.84 mm versus 9.44±1.07 mm (p<0.01) in SCAPs group and 0.9% NaCl group, respectively.

CT scan results showed a significant increase of 12.86 mm3 alveolar bone regeneration in SCAPs group compared with 0.9% NaCl group.

In addition, histopathology results demonstrated remarkable regeneration in SCAPs group, whereas regeneration of periodontal tissue was hardly found in 0.9% NaCl group.

Conclusion.

Local injection of SCAPs could effectively restore tissue defects brought about by periodontitis in the swine model.

Thus, SCAPs, as an easily accessible dental-deriving stem cell, may serve as an alternative application for periodontitis treatment.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Guoqing& Han, Nannan& Zhang, Xiuli& Yang, Haoqing& Cao, Yangyang& Wang, Songlin…[et al.]. 2018. Local Injection of Allogeneic Stem Cells from Apical Papilla Enhanced Periodontal Tissue Regeneration in Minipig Model of Periodontitis. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126247

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Guoqing…[et al.]. Local Injection of Allogeneic Stem Cells from Apical Papilla Enhanced Periodontal Tissue Regeneration in Minipig Model of Periodontitis. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1126247

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Guoqing& Han, Nannan& Zhang, Xiuli& Yang, Haoqing& Cao, Yangyang& Wang, Songlin…[et al.]. Local Injection of Allogeneic Stem Cells from Apical Papilla Enhanced Periodontal Tissue Regeneration in Minipig Model of Periodontitis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1126247

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1126247