Autoimmune Mechanisms of Interferon Hypersensitivity and Neurodegenerative Diseases: Down Syndrome
المؤلفون المشاركون
Jagadeesh, Ashraya
Maroun, Leonard E.
Van Es, Lisa M.
Millis, Richard M.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Down syndrome (DS), also known as trisomy 21 (T21), is associated with interferon (IFN) hypersensitivity, as well as predilections for Alzheimer’s dementia (AD) and various autoimmune diseases.
IFN-α and IFN-γ receptors are encoded on chromosome 21 (Ch21).
It remains unclear how other Ch21 genes contribute to the neuropathological features of DS/T21.
This study tests the hypothesis that identifying IFN-stimulated response element (ISRE) control sites on Ch21 will mark novel candidate genes for DS/T21-related IFN hypersensitivity and neuropathology not previously reported to be associated with IFN functions.
We performed whole chromosome searches of online databases.
The general ISRE consensus and gamma interferon activation consensus sequences (GAS) were used for identifying IFN-stimulated response elements.
Candidate genes were defined as those possessing two or more ISRE and/or GAS control sites within and/or upstream of the transcription start site.
A literature search of gene functions was used to select the candidate genes most likely to explain neuropathology associated with IFN hypersensitivity.
DOPEY2, TMEM50B, PCBP3, RCAN1, and SIM2 were found to meet the aforementioned gene search and functional criteria.
These findings suggest that DOPEY2, TMEM50B, PCBP3, RCAN1, and SIM2 are genes which may be dysregulated in DS/T21 and may therefore serve as novel targets for treatments aimed at ameliorating the neuropathological features of DS/T21.
Future studies should determine whether these genes are dysregulated in patients with DS, DS-related AD, and autoimmune diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jagadeesh, Ashraya& Maroun, Leonard E.& Van Es, Lisa M.& Millis, Richard M.. 2020. Autoimmune Mechanisms of Interferon Hypersensitivity and Neurodegenerative Diseases: Down Syndrome. Autoimmune Diseases،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1126248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jagadeesh, Ashraya…[et al.]. Autoimmune Mechanisms of Interferon Hypersensitivity and Neurodegenerative Diseases: Down Syndrome. Autoimmune Diseases No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1126248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jagadeesh, Ashraya& Maroun, Leonard E.& Van Es, Lisa M.& Millis, Richard M.. Autoimmune Mechanisms of Interferon Hypersensitivity and Neurodegenerative Diseases: Down Syndrome. Autoimmune Diseases. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1126248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر