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Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
المؤلفون المشاركون
Lee, Chien-Te
Lee, Wen-Chin
Chiou, Terry Ting-Yu
Wu, Chien-Hsing
Wu, Po-Jung
Ng, Hwee-Yeong
Lien, Shu-Ching
Tsai, Pei-Ying
Chen, Jin-Bor
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Nonalcoholic fatty liver disease (NAFLD) is becoming more common around the world and it may progress to cirrhosis and liver failure, increasing mortality risk.
In hemodialysis (HD) patients, NAFLD may be a novel risk factor for their high cardiovascular mortality.
Heightened oxidative stress is highly prevalent in HD patients.
However, the relationship between oxidative stress and NAFLD in HD patients is not well defined.
Methods.
We studied seventy-one stable nondiabetic HD patients.
Nineteen patients had the diagnosis of NAFLD by ultrasonography.
Blood levels of oxidative stress markers were measured in each patient, including thiobarbituric acid reactive substances (TBARS), free thiols, superoxide dismutase (SOD) activities, and glutathione peroxidase (GPx) activity.
The copy numbers of mitochondrial DNA (mtDNA) in peripheral leukocytes were also determined.
Demographic, biochemistry, and hemogram data were recorded.
The two groups of patients were compared in order to determine the factors associated with NAFLD in HD patients.
Findings.
Compared to those without NAFLD, nondiabetic HD patients with NAFLD had significantly higher mtDNA copy number and GPx levels.
The two groups did not differ significantly in dialysis adequacy, hemoglobin, serum calcium, phosphorus, albumin, liver function tests, or lipid profiles.
Regression analysis confirmed mtDNA copy numbers and GPx levels as two independent factors associated with NAFLD.
Compared to those with polysulfone, patients dialyzed with cellulose membrane have significantly higher levels of TBARS.
However, patients with or without NAFLD did not differ in their use of either dialysis membrane.
Discussion.
Oxidative stress (represented by antioxidant defense, GPx) and mitochondrial DNA copy numbers are independently associated with fatty liver disease in nondiabetic HD patients.
The diagnostic and therapeutic implications of this key observation warrant further exploration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Po-Jung& Chen, Jin-Bor& Lee, Wen-Chin& Ng, Hwee-Yeong& Lien, Shu-Ching& Tsai, Pei-Ying…[et al.]. 2018. Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Po-Jung…[et al.]. Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1126250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Po-Jung& Chen, Jin-Bor& Lee, Wen-Chin& Ng, Hwee-Yeong& Lien, Shu-Ching& Tsai, Pei-Ying…[et al.]. Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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