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Computational Investigation on the Biomechanical Responses of the Osteocytes to the Compressive Stimulus: A Poroelastic Model
المؤلفون المشاركون
Wang, Liping
Dong, Jianghui
Xian, Cory J.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-18
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Osteocytes, the major type of bone cells embedded in the bone matrix and surrounded by the lacunar and canalicular system, can serve as biomechanosensors and biomechanotranducers of the bone.
Theoretical analytical methods have been employed to investigate the biomechanical responses of osteocytes in vivo; the poroelastic properties have not been taken into consideration in the three-dimensional (3D) finite element model.
In this study, a 3D poroelastic idealized finite element model was developed and was used to predict biomechanical behaviours (maximal principal strain, pore pressure, and fluid velocity) of the osteocyte-lacunar-canalicular system under 150-, 1000-, 3000-, and 5000-microstrain compressive loads, respectively, representing disuse, physiological, overuse, and pathological overload loading stimuli.
The highest local strain, pore pressure, and fluid velocity were found to be highest at the proximal region of cell processes.
These data suggest that the strain, pore pressure, and fluid velocity of the osteocyte-lacunar-canalicular system increase with the global loading and that the poroelastic material property affects the biomechanical responses to the compressive stimulus.
This new model can be used to predict the mechanobiological behaviours of osteocytes under the four different compressive loadings and may provide an insight into the mechanisms of mechanosensation and mechanotransduction of the bone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Liping& Dong, Jianghui& Xian, Cory J.. 2018. Computational Investigation on the Biomechanical Responses of the Osteocytes to the Compressive Stimulus: A Poroelastic Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1126330
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Liping…[et al.]. Computational Investigation on the Biomechanical Responses of the Osteocytes to the Compressive Stimulus: A Poroelastic Model. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1126330
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Liping& Dong, Jianghui& Xian, Cory J.. Computational Investigation on the Biomechanical Responses of the Osteocytes to the Compressive Stimulus: A Poroelastic Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1126330
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126330
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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