Association between Alanine Aminotransferase and Growth Hormone: A Retrospective Cohort Study of Short Children and Adolescents
المؤلفون المشاركون
Pan, Hui
Ji, Baolan
Zhang, Mei
Zhao, Qianqian
Chu, Yuntian
Li, Yanying
Ban, Bo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
This study aimed to examine the relationship between serum alanine aminotransferase (ALT) and growth hormone (GH) in children and adolescents with short stature.
Methods.
In this retrospective cohort study, 670 Chinese children and adolescents with short stature were included, and 253 of them received recombinant human GH (rhGH) therapy.
Anthropometric and biochemical indicators were measured.
GH peak levels were assessed after provocation tests with L-dopa and insulin.
The subjects were divided into 3 groups according to the GH peak level.
The association between the GH peak and ALT was analyzed.
The change of ALT during rhGH therapy was assessed by a generalized additive mixed model.
Results.
Serum ALT and incidence of ALT elevation were both decreased across the GH tertiles (P = 0.002, 0.012, respectively).
A univariate analysis showed that the GH peak was negatively associated with ALT (β: -0.12; 95%CI: -0.22, -0.02; P = 0.023).
Furthermore, multiple linear stepwise regression analysis demonstrated that the GH peak was independently related to ALT after adjusting for other confounding variables (β: -0.12; 95%CI: -0.24, -0.00; P = 0.042).
Besides, mean values of the change in ALT from baseline displayed that, during the early stages of rhGH treatment, serum ALT level indicated a temporary upward trend, but it subsequently gradually decreased (β: -0.16; 95%CI: -0.23, -0.09; P < 0.001).
Conclusions.
GH secretion level was strongly negatively correlated with ALT in short children and adolescents.
And rhGH therapy could reduce ALT level over time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ji, Baolan& Zhang, Mei& Zhao, Qianqian& Chu, Yuntian& Li, Yanying& Pan, Hui…[et al.]. 2019. Association between Alanine Aminotransferase and Growth Hormone: A Retrospective Cohort Study of Short Children and Adolescents. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126343
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ji, Baolan…[et al.]. Association between Alanine Aminotransferase and Growth Hormone: A Retrospective Cohort Study of Short Children and Adolescents. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1126343
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ji, Baolan& Zhang, Mei& Zhao, Qianqian& Chu, Yuntian& Li, Yanying& Pan, Hui…[et al.]. Association between Alanine Aminotransferase and Growth Hormone: A Retrospective Cohort Study of Short Children and Adolescents. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126343
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126343
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر