Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1Th2 Imbalance in RP Rats
المؤلفون المشاركون
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Studying correlative changes of Th1/Th2 (Th, Helper T cells) related factor Interferon-γ (IFN-γ) and Interleukin-4 (IL-4) in the progression of radiation pneumonia (RP) rats and the efficacy of Shashen-Maidong decoction on these indexes to explore the immune mechanism of the decoction on the prevention and treatment of RP.
Methods.
Male 60 Sprague-Dawley (SD) rats were randomly divided into four groups.
In addition to the normal control group taking saline, the other rats were set up RP model treated with Shashen-Maidong decoction or dexamethasone (DXM), respectively.
The IFN-γ and IL-4 concentrations in serum and bronchoalveolar lavage fluid (BALF) of rats were tested in the 2nd and 4th week after radiation, and the relative ratio of IFN-γ/IL-4 was calculated.
Results.
(1) There was significant difference of serum IL-4 concentrations in group B (p<0.01) and extreme difference in groups C and D (p<0.001) compared with group A in 4th week.
Compared with group D, IL-4 concentrations in group B increased significantly in both 2nd and 4th week (p<0.01).
Group B had significantly decreased IFN-γ concentrations in BALF (p<0.001) compared with group D in the 4th week.
And IFN-γ concentrations in BALF in group B were increased compared with group C in the 4th week (p<0.05).
(2) There was no difference of the relative ratio of IFN-γ/IL-4 at each time in groups B and A for both serum and BALF, while the ratios in groups C and D in 4th week in BALF were increased (p<0.05) compared to group A.
Conclusion.
Shashen-Maidong decoction can improve the immune function of RP rats by increasing IFN-γ concentration and decreasing IL-4 concentration, possibly by increasing the relative ratio of IFN-γ/IL-4 to regulate the immune imbalance of Th1/Th2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Yuan& Zhou, Yanping. 2019. Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1Th2 Imbalance in RP Rats. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126389
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Yuan& Zhou, Yanping. Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1Th2 Imbalance in RP Rats. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1126389
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Yuan& Zhou, Yanping. Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1Th2 Imbalance in RP Rats. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1126389
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126389
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر