Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese
المؤلفون المشاركون
Doucette, Kimberley
Latif, Hira
Vakiti, Anusha
Tefera, Eshetu
Patel, Bhavisha
Fitzpatrick, Kelly
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Obesity plays an essential role in the safety of pharmacologic drugs.
There is paucity of data for direct oral anticoagulants (DOACs) in the obese, despite these agents becoming more widely used.
The primary and secondary objectives of this study were to assess the safety and efficacy of DOACs in the overweight and obese populations when used for primary prophylaxis in the setting of non-valvular atrial fibrillation (NVAF) and for treatment of venous thromboembolisms (VTE).
We conducted a retrospective cohort study in a large tertiary care center and obtained data through review of electronic health records.
Among patients with NVAF and VTE on apixaban, there were no differences in rates of major bleeding (MB) and clinically relevant nonmajor bleeding (CRNMB) in the overweight and obese populations when compared to normal weight and underweight individuals.
The multivariate adjusted analysis for rivaroxaban found that the odds of CRNMB for patients with BMI <25 was 5.37 (95% CI 1.50–19.32) times higher than that of BMI ≥25.
Moreover, patients on medications that had known interactions with DOACs had 6.40 times higher odds of CRNMB than patients without such interactions (95% CI 1.49–27.57), which was not accounted for by the effects of aspirin and plavix alone.
Efficacy was similar between all weight groups, for both apixaban and rivaroxaban.
These results support previous analyses preformed in the large phase III trials and confirm that apixaban and rivaroxaban are safe in the overweight and obese.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Doucette, Kimberley& Latif, Hira& Vakiti, Anusha& Tefera, Eshetu& Patel, Bhavisha& Fitzpatrick, Kelly. 2020. Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese. Advances in Hematology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126425
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Doucette, Kimberley…[et al.]. Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese. Advances in Hematology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1126425
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Doucette, Kimberley& Latif, Hira& Vakiti, Anusha& Tefera, Eshetu& Patel, Bhavisha& Fitzpatrick, Kelly. Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese. Advances in Hematology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1126425
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126425
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر