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Assessment of Confirmed Clinical Hypersensitivity to Rituximab in Patients Affected with B-Cell Neoplasia
المؤلفون المشاركون
Novelli, Silvana
Sierra, Jorge
Soto, L.
Caballero, A.
Moreno, M. E.
Lara, M. J.
Bayo, D.
Quintas, A.
Jimeno, P.
Zamora, M. I.
Bigorra, T.
Briones, Javier
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-11
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Rituximab hypersensitivity reactions are rare but are one of the main causes of rituximab elimination from antilymphoma immunochemotherapy treatments.
While the clinical picture may be indistinguishable from other infusion-related reactions, hypersensitivity reactions (HSR) do not disappear and instead become more intense with subsequent administrations.
Objective.
To describe the use of the 12-step protocol for desensitization to intravenous rituximab in clinical practice and the complementary study of a possible IgE-mediated HSR in the context of B-cell lymphoma treatment.
Methods.
A 12-step rituximab desensitization protocol was performed prospectively within clinical practice in 10 patients with a history of severe infusion reactions or in patients who had a repeated reaction at subsequent doses despite taking more intense preventive measures.
Skin prick tests were performed at the time of reaction and at a later time to eliminate false negatives due to possible drug interference.
Results.
Overall, with the desensitization protocol, 70% of patients were able to complete the scheduled immunochemotherapy.
Two patients had to discontinue the therapy due to clinical persistence and the third due to lymphoma progression.
Intradermal tests with 0.1% rituximab were positive in only 20% of cases, demonstrating a mechanism of hypersensitivity.
Conclusions.
The 12-step desensitization protocol is very effective and assumable within healthcare practice.
There is a need to determine the mechanism underlying the infusion reaction in a large proportion of cases due to the risk of future drug exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Novelli, Silvana& Soto, L.& Caballero, A.& Moreno, M. E.& Lara, M. J.& Bayo, D.…[et al.]. 2020. Assessment of Confirmed Clinical Hypersensitivity to Rituximab in Patients Affected with B-Cell Neoplasia. Advances in Hematology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1126429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Novelli, Silvana…[et al.]. Assessment of Confirmed Clinical Hypersensitivity to Rituximab in Patients Affected with B-Cell Neoplasia. Advances in Hematology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1126429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Novelli, Silvana& Soto, L.& Caballero, A.& Moreno, M. E.& Lara, M. J.& Bayo, D.…[et al.]. Assessment of Confirmed Clinical Hypersensitivity to Rituximab in Patients Affected with B-Cell Neoplasia. Advances in Hematology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1126429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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