![](/images/graphics-bg.png)
Enhanced Hypercoagulability in Sickle Cell Anaemia Patients with Chronic Leg Ulcers
المؤلفون المشاركون
Sackey, David
Dei-Adomakoh, Yvonne
Olayemi, Edeghonghon
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Sickle Cell Anaemia (SCA) is associated with a hypercoagulable state resulting in a predisposition to venous thromboembolism.
With improvements in the quality of care, more patients with SCA survive into adulthood with an associated increase in the frequency of end-organ damage and chronic complications such as chronic leg ulcers (CLUs).
These ulcers rarely occur in the first decade of life and are recurrent, painful, and slow-to-heal.
This study tested the hypothesis that coagulation is enhanced in SCA patients with CLU.
145 participants (50 SCA with CLU, 50 SCA without CLU, and 45 with haemoglobin AA) were assessed to determine their coagulation profile using selected tests of coagulation.
The SCA with the CLU group had the lowest mean haemoglobin (Hb) concentration.
SCA patients with and without CLUs had elevated mean platelet counts, shorter mean aPTT, and marginally prolonged mean PT compared to HbAA patients.
SCA with CLUs patients had a significantly shortened aPTT than those without CLUs (p = 0.035) and HbAA (p = 0.009).
There were significant differences in the mean PT between SCA with CLUs patients and HbAA (p = 0.017); SCA without CLU and HbAA (p = 0.014).
SCA with and without CLUs patients had higher mean D-dimer levels compared to HbAA.
There was a negative correlation between Hb concentration and duration of CLU (r = -0.331, p = 0.021).
In conclusion, our study demonstrates a heightened hypercoagulability in SCA patients with CLUs.
We did not test for platelet activation, and it is not clear what role, if any, the enhanced hypercoagulability plays in the pathogenesis of CLUs in SCA.
It will be useful to ascertain if antiplatelet agents or/and anticoagulants quicken the healing of CLUs in SCA patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sackey, David& Dei-Adomakoh, Yvonne& Olayemi, Edeghonghon. 2020. Enhanced Hypercoagulability in Sickle Cell Anaemia Patients with Chronic Leg Ulcers. Advances in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1126433
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sackey, David…[et al.]. Enhanced Hypercoagulability in Sickle Cell Anaemia Patients with Chronic Leg Ulcers. Advances in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1126433
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sackey, David& Dei-Adomakoh, Yvonne& Olayemi, Edeghonghon. Enhanced Hypercoagulability in Sickle Cell Anaemia Patients with Chronic Leg Ulcers. Advances in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1126433
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126433
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)