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Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study
المؤلفون المشاركون
Allotey, Emmanuel Alote
Awaitey, Daniel Kpodji
Akorsu, Elliot Elikplim
Kwasie, David Annor
Kwadzokpui, Precious Kwablah
Tawiah, Philip Apraku
Amankwah, Stephen Adomako
Abaka-Yawson, Albert
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
It is estimated that one out of every three Ghanaians has hemoglobin genotype mutation.
This change in genetic make-up may result in genotypes such as HbAS, HbSS, and HbSC.
Many children in low- and middle-income countries die even before they are diagnosed with sickle cell disease (SCD).
In Africa, there are limited data on the incidence and prevalence of SCD and the Volta region of Ghana is no exception.
Aim.
The aim of this study was to determine the prevalence of SCD and to assess the hemoglobin variants among patients attending Ho Teaching Hospital.
Methods.
A retrospective study design was used to extract information from the Hospital Administration and Management Systems (HAMS) on the hemoglobin electrophoresis results and corresponding full blood count results of the SCD and sickle cell anemia (SCA) patients as well as patients who were asked to do Hb electrophoresis irrespective of their sickling status.
Data were collected for the period January 2016 to December 2018.
Sickle cell disease status was determined using the Hb genotypes from the Hb electrophoresis results.
The full blood count was used to categorize the severity of anemia based on the hemoglobin concentration in the SCA and SCD patients.
Results.
A total of 1,523 subjects were included in the study of which the prevalence for sickle cell disease was 16.7%.
The SCD genotypes included HbS (6.2%), HbSC (7.9%), and HbSF (2.6%).
Hemoglobin C disease (HbCC) constituted 0.3% out of the total prevalence of SCD.
The prevalence of anemia was 99.2%, with the severest form in HbS.
Also, majority of the SCD patients had severe anemia.
Difference in the severity of anemia was found to be significant among both male (P=0.006) and female (P=0.004) participants with SCD.
Conclusion.
Patients receiving health care at the Ho Teaching Hospital had different hemoglobin variants with HbAS recording the highest prevalence.
The high incidence of hemoglobin AS implies the possibility of having an increased population of individuals with sickle cell disease in future if measures are not put in place to improve screening, counseling, and education of the public about the health threat SCD poses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Awaitey, Daniel Kpodji& Akorsu, Elliot Elikplim& Allotey, Emmanuel Alote& Kwasie, David Annor& Kwadzokpui, Precious Kwablah& Tawiah, Philip Apraku…[et al.]. 2020. Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study. Advances in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1126438
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Awaitey, Daniel Kpodji…[et al.]. Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study. Advances in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1126438
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Awaitey, Daniel Kpodji& Akorsu, Elliot Elikplim& Allotey, Emmanuel Alote& Kwasie, David Annor& Kwadzokpui, Precious Kwablah& Tawiah, Philip Apraku…[et al.]. Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study. Advances in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1126438
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126438
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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