The Role of Gut Microbiome Perturbation in Fatigue Induced by Repeated Stress from Chemoradiotherapy: A Proof of Concept Study

المؤلفون المشاركون

Saligan, Leorey
Henderson, Wendy A.
Groer, Maureen
González-Mercado, Velda J.
Pérez-Santiago, Josué
Lyon, Debra
Dilán-Pantojas, Israel
McMillan, Susan
Kane, Brad
Marrero, Sara
Pedro, Elsa

المصدر

Advances in Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-02-07

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الطب البشري

الملخص EN

Objectives.

The objectives of this proof of concept study were to (a) examine the temporal changes in fatigue and diversity of the gut microbiome over the course of chemoradiotherapy (CRT) in adults with rectal cancers; (b) investigate whether there are differences in diversity of the gut microbiome between fatigued and nonfatigued participants at the middle and at the end of CRT; and (c) investigate whether there are differences in the relative abundance of fecal microbiota at the phylum and genus levels between fatigued and nonfatigued participants at the middle and at the end of CRT.

Methods.

Stool samples and symptom ratings were collected prior to the inception of CRT, at the middle (after 12–16 treatments) and at the end (after 24–28 treatments) of the CRT.

Descriptive statistics and Mann–Whitney U test were computed for fatigue.

Gut microbiome data were analyzed using the QIIME2 software.

Results.

Participants (N = 29) ranged in age from 37 to 80 years.

The median fatigue score significantly changed at the end of CRT (median = 23.0) compared with the median score before the initiation of CRT for the total sample (median = 17.0; p≤0.05).

At the middle of CRT, the alpha diversity (abundance of Operational Taxonomic Units) was lower for fatigued participants (149.30 ± 53.1) than for nonfatigued participants (189.15 ± 44.18, t(23) = 2.08, p≤0.05).

A similar trend was observed for the Shannon and Faith diversity indexes at the middle of CRT.

However, at the end of CRT, there were no significant differences for any alpha diversity indexes between fatigued and nonfatigued participants.

Proteobacteria, Firmicutes, and Bacteroidetes were the dominant phyla for fatigued participants, and Escherichia, Bacteroides, Faecalibacterium, and Oscillospira were the most abundant genera for fatigued participants.

Conclusion.

CRT-associated perturbation of the gut microbiome composition may contribute to fatigue.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

González-Mercado, Velda J.& Pérez-Santiago, Josué& Lyon, Debra& Dilán-Pantojas, Israel& Henderson, Wendy A.& McMillan, Susan…[et al.]. 2020. The Role of Gut Microbiome Perturbation in Fatigue Induced by Repeated Stress from Chemoradiotherapy: A Proof of Concept Study. Advances in Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1126736

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

González-Mercado, Velda J.…[et al.]. The Role of Gut Microbiome Perturbation in Fatigue Induced by Repeated Stress from Chemoradiotherapy: A Proof of Concept Study. Advances in Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1126736

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

González-Mercado, Velda J.& Pérez-Santiago, Josué& Lyon, Debra& Dilán-Pantojas, Israel& Henderson, Wendy A.& McMillan, Susan…[et al.]. The Role of Gut Microbiome Perturbation in Fatigue Induced by Repeated Stress from Chemoradiotherapy: A Proof of Concept Study. Advances in Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1126736

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1126736