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P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin
المؤلفون المشاركون
Li, Qi
Ren, Liqun
Zhang, Yang
Gu, Zehui
Tan, Qi
Zhang, Tong
Qin, Meng
Chen, Suxian
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Currently, gastric cancer treatment is mainly based on first-line intervention with oxaliplatin (OXA) after surgical resection, but the application of OXA has been limited due to the toxic side effects caused by the cumulative dose.
The toxicity of OXA mainly includes hepatotoxicity, nephrotoxicity, and ototoxicity, and there is an urgent clinical need to find alternatives that are less toxic and more effective.
Rutin (RT) is a natural flavonoid with many biological activities.
Studies have found that RT inhibits tumor cell growth and enhances their sensitivity toward certain drugs.
As the underlying impact of RT on gastric cancer and its molecular mechanism remain poorly understood, we performed a series of experiments to determine whether RT has the effect of treating gastric cancer, and whether it can cooperate with OXA to treat gastric cancer and its related mechanisms.
In the present study, we founded that RT suppressed cell viability, inhibited cell proliferation by causing G0/G1 arrest, and induced apoptosis in SGC 7901 cells.
And RT can play as an antitumor agent together with OXA.
The mechanism of RT-induced apoptosis may be associated with the activation of the p38/Caspase signal pathway.
These results demonstrated the potential of RT as a promising therapeutic compound to treat gastric cancer.
At the same time, RT can synergize with OXA to reduce the dose of OXA and reduce the toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Qi& Ren, Liqun& Zhang, Yang& Gu, Zehui& Tan, Qi& Zhang, Tong…[et al.]. 2019. P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126747
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Qi…[et al.]. P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1126747
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Qi& Ren, Liqun& Zhang, Yang& Gu, Zehui& Tan, Qi& Zhang, Tong…[et al.]. P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1126747
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126747
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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