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Serum Adipocyte Fatty Acid-Binding Protein 4 Levels Are Independently Associated with Radioisotope Glomerular Filtration Rate in Type 2 Diabetic Patients with Early Diabetic Nephropathy
المؤلفون المشاركون
Jia, Weiping
Ni, Xiaoqing
Gu, Yunjuan
Wang, Shenqi
Chen, Ying
Wang, Xinlei
Yuan, Xinlu
Yu, Haoyong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Serum fatty acid-binding protein 4 (FABP4) has been linked to renal dysfunction.
This study evaluated the association between serum FABP4 and the radioisotope glomerular filtration rate (rGFR) in type 2 diabetic patients (T2DM) with early diabetic nephropathy.
Twenty healthy controls and 172 patients with T2DM were enrolled.
Serum FABP4 and renal impairment biomarkers including urinary albumin-to-creatinine ratio (UACR), serum retinal-binding protein 4 (RBP4), urinary cystatin C-to-creatinine ratio (CysC/Cr), and neutrophil gelatinase-associated lipocalin-to-creatinine ratio (NGAL/Cr) were measured.
Diethylenetriaminepentaacetic acid (99mTc-DTPA) was used to test rGFR.
Serum FABP4 levels were higher in T2DM patients compared with the controls.
There was no significant correlation between serum FABP4 and UACR in patients with T2DM.
Multivariate stepwise regression analysis showed that, in patients with T2DM, FABP4 was significantly associated with rGFR while CysC/Cr and RBP4 were significantly associated with UACR independently.
But UACR had no independent association with rGFR.
NGAL/Cr had no significant correlation with either rGFR or UACR.
FABP4 might be an early biomarker for diabetic nephropathy if combined with UACR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ni, Xiaoqing& Gu, Yunjuan& Yu, Haoyong& Wang, Shenqi& Chen, Ying& Wang, Xinlei…[et al.]. 2018. Serum Adipocyte Fatty Acid-Binding Protein 4 Levels Are Independently Associated with Radioisotope Glomerular Filtration Rate in Type 2 Diabetic Patients with Early Diabetic Nephropathy. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ni, Xiaoqing…[et al.]. Serum Adipocyte Fatty Acid-Binding Protein 4 Levels Are Independently Associated with Radioisotope Glomerular Filtration Rate in Type 2 Diabetic Patients with Early Diabetic Nephropathy. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ni, Xiaoqing& Gu, Yunjuan& Yu, Haoyong& Wang, Shenqi& Chen, Ying& Wang, Xinlei…[et al.]. Serum Adipocyte Fatty Acid-Binding Protein 4 Levels Are Independently Associated with Radioisotope Glomerular Filtration Rate in Type 2 Diabetic Patients with Early Diabetic Nephropathy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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