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Excess Glutamate May Cause Dilation of Retinal Blood Vessels in GlutamateAspartate Transporter-Deficient Mice
المؤلفون المشاركون
Gonome, Takayuki
Xie, Yuting
Arai, Saeko
Yamauchi, Kodai
Maeda-Monai, Natsuki
Tanabu, Reiko
Kudo, Takashi
Nakazawa, Mitsuru
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the longitudinal findings of fundus features and spectral-domain optical coherence tomography (SD-OCT) to characterize the morphologic features in a mouse model of defective glutamate/aspartate transporter (GLAST−/− mice).
Materials and Methods.
The fundus findings and SD-OCT images were longitudinally recorded at five time points from postnatal (P) 22 to P156 in GLAST−/− mice.
As a control wild type, age-matched C57BL/6J mice were employed.
The mouse retina was subdivided into five layers, and the thickness of each layer was longitudinally measured by InSight® using SD-OCT pictures.
The SD-OCT findings were compared with the histologic appearances.
The diameter of the retinal blood vessels was measured by the ImageJ® software program using SD-OCT images.
The data were statistically compared between both age-matched mouse groups.
Results.
The retinal blood vessels appeared more dilated in GLAST−/− mice than in wild-type mice.
This tendency was statistically significant at all time points after P44 by analyses using SD-OCT images.
The ganglion cell complex (GCC) and outer nuclear layer (ONL) were significantly thinner in GLAST−/− mice at all time points after P80 than in the wild-type mice.
This tendency was more clearly indicated by SD-OCT than histologic sections.
Discussion.
In the present study, we found for the first time the dilation of the retinal blood vessels and the thinning of the ONL in GLAST−/− mice, in addition to the thinning of the GCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gonome, Takayuki& Xie, Yuting& Arai, Saeko& Yamauchi, Kodai& Maeda-Monai, Natsuki& Tanabu, Reiko…[et al.]. 2019. Excess Glutamate May Cause Dilation of Retinal Blood Vessels in GlutamateAspartate Transporter-Deficient Mice. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gonome, Takayuki…[et al.]. Excess Glutamate May Cause Dilation of Retinal Blood Vessels in GlutamateAspartate Transporter-Deficient Mice. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1126807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gonome, Takayuki& Xie, Yuting& Arai, Saeko& Yamauchi, Kodai& Maeda-Monai, Natsuki& Tanabu, Reiko…[et al.]. Excess Glutamate May Cause Dilation of Retinal Blood Vessels in GlutamateAspartate Transporter-Deficient Mice. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1126807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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