Prognostic and Clinicopathological Value of PINX1 in Various Human Tumors: A Meta-Analysis
المؤلفون المشاركون
Kong, Weihao
Liang, Hao
Xiong, Zhiyong
Li, Ying
Li, Ruixi
Deng, Meihai
Hu, Kunpeng
Yao, Zhicheng
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
PINX1 (Pin2/TRF1 interacting protein X1, an intrinsic telomerase inhibitor and putative tumor suppressor gene) may represent a novel prognostic tumor biomarker.
However, the results of previous studies are inconsistent and the prognostic value of PINX1 remains controversial.
Therefore, we conducted a meta-analysis to determine whether PINX1 expression is associated with overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), recurrence-free survival (RFS), and clinicopathological characteristics in patients with malignant tumors.
A systematic search was performed in the PubMed, Web of Science, and Embase databases in April 2018.
Quality assessment was performed according to the modified Newcastle-Ottawa Scale.
Pooled odds ratios (ORs) and hazard ratios (HRs) with 95.0% confidence intervals (CIs) were calculated to determine the relationship between PINX1 expression and OS, DSS, DFS/RFS, and clinicopathological characteristics.
Due to the heterogeneity across the included studies, subgroup and sensitivity analyses were performed.
Fixed-effects models were used when the heterogeneity was not significant and random-effects models were used when the heterogeneity was significant.
Fourteen studies of 16 cohorts including 2,624 patients were enrolled.
Low PINX1 expression was associated with poor OS (HR: 1.51, 95.0% CI: 1.03–2.20; P = 0.035) and DFS/RFS (HR: 1.78, 95.0% CI: 1.28–2.47; P = 0.001) but not DSS (HR: 0.80, 95.0% CI: 0.38–1.67; P = 0.548).
Low PINX1 expression was also associated with lymphatic invasion (OR: 2.23, 95.0% CI: 1.35–3.70; P = 0.002) and advanced tumor-node-metastasis stage (OR: 2.43, 95.0% CI: 1.29–4.57; P = 0.006).
No significant associations were observed between low PINX1 expression and sex, depth of invasion, grade of differentiation, and distant metastasis.
Low PINX1 expression was associated with poor OS and DFS/RFS and lymphatic invasion and advanced tumor-node-metastasis stage, suggesting that PINX1 expression may be a useful predictor of prognosis in patients with malignant tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Hao& Xiong, Zhiyong& Li, Ying& Kong, Weihao& Yao, Zhicheng& Li, Ruixi…[et al.]. 2018. Prognostic and Clinicopathological Value of PINX1 in Various Human Tumors: A Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Hao…[et al.]. Prognostic and Clinicopathological Value of PINX1 in Various Human Tumors: A Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1126813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Hao& Xiong, Zhiyong& Li, Ying& Kong, Weihao& Yao, Zhicheng& Li, Ruixi…[et al.]. Prognostic and Clinicopathological Value of PINX1 in Various Human Tumors: A Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1126813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر