Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension
المؤلفون المشاركون
Dias-Junior, Carlos A.
Gonçalves-Rizzi, Victor H.
Possomato-Vieira, José Sérgio
Nascimento, Regina Aparecida do
Wandekin, Rodrigo Roldão
Caldeira-Dias, Mayara
Chimini, Jessica Sabbatine
da Silva, Maria Luiza Santos
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-28
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H2S) have been reported previously.
However, no studies examined involvement of H2S in Pb-induced hypertension.
We found increases in diastolic blood pressure and mean blood pressure in Pb-intoxicated humans followed by diminished H2S plasmatic levels.
In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS.
Pb-intoxicated animals received intraperitoneally (i.p.) 1st dose of 8 μg/100 g of Pb acetate and subsequent doses of 0.1 μg/100 g for seven days and sodium hydrosulfide- (NaHS-) treated animals received i.p.
NaHS injections (50 μmol/kg/twice daily) for seven days.
NaHS treatment blunted increases in systolic blood pressure, increased H2S plasmatic levels, and diminished whole-blood lead levels.
Treatment with NaHS in Pb-induced hypertension seems to induce a protective role in rat aorta which is dependent on endothelium and seems to promote non-NO-mediated relaxation.
Pb-intoxication increased oxidative stress in rats, while treatment with NaHS blunted increases in plasmatic MDA levels and increased antioxidant status of plasma.
Therefore, H2S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Possomato-Vieira, José Sérgio& Gonçalves-Rizzi, Victor H.& Nascimento, Regina Aparecida do& Wandekin, Rodrigo Roldão& Caldeira-Dias, Mayara& Chimini, Jessica Sabbatine…[et al.]. 2018. Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126815
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Possomato-Vieira, José Sérgio…[et al.]. Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1126815
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Possomato-Vieira, José Sérgio& Gonçalves-Rizzi, Victor H.& Nascimento, Regina Aparecida do& Wandekin, Rodrigo Roldão& Caldeira-Dias, Mayara& Chimini, Jessica Sabbatine…[et al.]. Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1126815
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126815
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر