Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients with β-Thalassemia Major: A Meta-Analysis
المؤلفون المشاركون
Sun, Xiaofang
He, Li-Na
Chen, Wei
Yang, Yi
Xie, Ying-Jun
Xiong, Ze-Yu
Chen, Di-Yu
Lu, Dian
Liu, Neng-Qing
Yang, Ying-Hong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Endocrinopathies are common in patients with β-thalassemia major despite parenteral iron chelation therapy with deferoxamine.
Prevalence of abnormal glucose metabolism in previous studies was controversial.
The aim of this study was to discuss the prevalence of abnormal glucose metabolism in β-thalassemia major based on a meta-analysis.
Methods.
PubMed, ScienceDirect, Springerlink, Ovid, Web of Science, MEDLINE, Wanfang database, and Chinese National Knowledge Internet were searched for relevant articles.
Two authors selected the articles according to the inclusion criteria and then extracted the data.
The prevalence of diabetes mellitus (DM) in β-thalassemia major was defined as the primary outcome.
The prevalence with the 95% confidence interval (95%CI) was used to evaluate the proportion of abnormal glucose metabolism and other endocrine disorders in patients with β-thalassemia major.
Subgroup analyses were applied to explore the prevalence in different regions.
Sensitivity analysis and publication bias assessment were also conducted.
Results.
A total of 44 studies with 16605 cases were included in this analysis.
Diabetes mellitus was present in 6.54% (95% CI: 5.30%-7.78%).
The fixed subgroup study revealed that the region with the highest prevalence was the Middle East (prevalence= 7.90%, 95% CI: 5.75%-10.05%).
The accumulated meta-analysis revealed that the prevalence of DM in β-thalassemia major was relatively steady in each year.
The prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and other endocrine disorders in β-thalassemia major was 17.21% (95% CI: 8.43%-26.00%), 12.46% (95% CI: 5.98%-18.94%), and 43.92% (95% CI: 37.94%-49.89%), respectively.
Sensitivity analysis showed that the pooled results were robust; publication bias assessment revealed that there was no significant evidence that the pooled results were influenced by publication bias.
Conclusion.
High prevalence of endocrine disorders involving abnormal glucose metabolism was detected in β-thalassemia major.
Treatment and prevention measurements may be necessary to prevent growth and endocrine problems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Li-Na& Chen, Wei& Yang, Yi& Xie, Ying-Jun& Xiong, Ze-Yu& Chen, Di-Yu…[et al.]. 2019. Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients with β-Thalassemia Major: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1126843
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Li-Na…[et al.]. Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients with β-Thalassemia Major: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1126843
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Li-Na& Chen, Wei& Yang, Yi& Xie, Ying-Jun& Xiong, Ze-Yu& Chen, Di-Yu…[et al.]. Elevated Prevalence of Abnormal Glucose Metabolism and Other Endocrine Disorders in Patients with β-Thalassemia Major: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1126843
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126843
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر