Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis
المؤلفون المشاركون
Zhong, Yisheng
Huang, Shouyue
Lin, Zhongjing
Xie, Bing
Sun, Jun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-24
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Previous studies exploring the association between toll-like receptor 4 (TLR4) polymorphisms and open angle glaucoma (OAG) presented inconsistent results.
We aimed to investigate the association between TLR4 polymorphisms and OAG.
Methods.
A systematic literature search was conducted in PubMed, EMBASE, ISI Web of Knowledge, and the Cochrane Library up to 31 December 2018.
Odds ratio (OR) and 95% confidence interval (95%CI) were calculated, followed by stratification analyses according to ethnicity and glaucoma subtype.
Results.
TLR4 rs7037117 polymorphism had significant associations with increased risk of OAG in allelic model (OR=1.25; 95%CI: 1.09-1.44; P=0.002) and recessive model (OR=1.49; 95%CI: 1.08-2.04; P=0.01).
With regard to rs10759930, rs12377632, and rs2149356, the results showed significant increased risks in all genetic models (all P<0.05), whereas, for rs1927914, rs11536889, and rs7045953, no significant associations were identified in any genetic model (all P>0.05).
Furthermore, the association of rs1927911 with OAG risk was found to be significant in recessive model (OR=1.34; 95%CI: 1.06-1.71; P=0.02).
As for rs4986790 and rs4986791, meta-analyses were not performed due to the limited number of studies and the ethnic differences.
Subgroup analysis indicated that the above polymorphisms with significant differences might increase the susceptibility in POAG patients.
As for the ethnicity, rs7037117, rs10759930, and rs1927911 might increase the risk in Asians, while rs12377632 and rs2149356 might increase the risk in Asians and Mexicans.
Conclusion.
The meta-analysis highlighted that certain mutations of some TLR4 polymorphisms might increase the susceptibility of OAG.
However, TLR4 polymorphisms are still far from being candidate genetic biomarkers for OAG.
Additional researches involving larger scale epidemiological studies are warranted to validate our results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Zhongjing& Huang, Shouyue& Sun, Jun& Xie, Bing& Zhong, Yisheng. 2019. Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1126874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Zhongjing…[et al.]. Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1126874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Zhongjing& Huang, Shouyue& Sun, Jun& Xie, Bing& Zhong, Yisheng. Associations between TLR4 Polymorphisms and Open Angle Glaucoma: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1126874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر