Alkaline Phosphatase Kinetics Predict Metastasis among Prostate Cancer Patients Who Experience Relapse following Radical Prostatectomy
المؤلفون المشاركون
Salter, Carolyn A.
Kuo, Claire
Hurwitz, Lauren
Metwalli, Adam R.
Dimitrakoff, Jordan
Rosner, Inger L.
Chen, Yongmei
Cullen, Jennifer
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Metastasis prostate cancer (CaP) occurs in a small fraction of patients.
Improved prognostication of disease progression is a critical challenge.
This study examined alkaline phosphatase velocity (APV) in predicting distant metastasis-free survival (DMFS).
Materials and Methods.
This retrospective cohort study examined CaP patients enrolled in the Center for Prostate Disease Research (CPDR) multicenter national database who underwent RP and experienced BCR (n=1783).
BCR was defined as a PSA ≥ 0.2 ng/mL at ≥ 8 weeks post-RP, followed by at least one confirmatory PSA ≥ 0.2 ng/mL or initiation of salvage therapy.
APV was computed as the slope of the linear regression line of all alkaline phosphatase (AP) values after BCR and prior to distant metastasis.
APV values in the uppermost quartile were defined as “rapid” and compared to the lower three quartiles combined (“slower”).
Unadjusted Kaplan Meier (KM) estimation curves and multivariable Cox proportional hazards analysis were used to examine predictors of DMFS.
Results.
Of the 1783 eligible patients who experienced post-RP BCR, 701 (39.3%) had necessary AP data for APV calculation.
PSA doubling time (PSADT) and APV were strongly associated (p=0.008).
No differences in APV were observed across race.
In KM analysis, significantly poorer DMFS was observed among the rapid versus slower APV group (Log-rank p=0.003).
In multivariable analysis, a rapid APV was predictive of a twofold increased probability of DMFS (HR = 2.2; 95% CI = 1.2, 3.9; p = 0.008), controlling for key study covariates.
Conclusions.
Building on previous work, this study found that rapid APV was a strong predictor of DMFS for a broader group of CaP patients, those who undergo post-RP BCR who were enrolled in a longitudinal cohort with long-term follow-up and equal health care access.
APV is worth considering as a complementary clinical factor for predicting DMFS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salter, Carolyn A.& Cullen, Jennifer& Kuo, Claire& Chen, Yongmei& Hurwitz, Lauren& Metwalli, Adam R.…[et al.]. 2018. Alkaline Phosphatase Kinetics Predict Metastasis among Prostate Cancer Patients Who Experience Relapse following Radical Prostatectomy. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salter, Carolyn A.…[et al.]. Alkaline Phosphatase Kinetics Predict Metastasis among Prostate Cancer Patients Who Experience Relapse following Radical Prostatectomy. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1126875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salter, Carolyn A.& Cullen, Jennifer& Kuo, Claire& Chen, Yongmei& Hurwitz, Lauren& Metwalli, Adam R.…[et al.]. Alkaline Phosphatase Kinetics Predict Metastasis among Prostate Cancer Patients Who Experience Relapse following Radical Prostatectomy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1126875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر