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Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast
المؤلفون المشاركون
Miles, Jana S.
Flores-Rozas, Hernan
Sojourner, Samantha J.
Whitmore, Aurellia M.
Freeny, Devon
Darling-Reed, Selina
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Anthracyclines are frequently used to treat many cancers including triple negative breast cancer, which is commonly observed in African-American women (AA), and tend to be more aggressive, carry worse prognoses, and are harder to manage because they lack molecular targets.
Although effective, anthracyclines use can be limited by serious side effects and eventually the development of drug resistance.
In S.
cerevisiae, mutants of HOM6 display hypersensitivity to doxorubicin.
HOM6 is required for synthesis of threonine and interruption of the pathway leads to accumulation of the threonine intermediate L-aspartate-semialdehyde.
This intermediate may synergize with doxorubicin to kill the cell.
In fact, deleting HOM3 in the first step, preventing the pathway to reach the HOM6 step, rescues the sensitivity of the hom6 strain to doxorubicin.
Using several S.
cerevisiae strains (wild type, hom6, hom3, hom3hom6, ydj1, siz1, and msh2), we determined their sensitivity to aldehydes and to their combination with doxorubicin, cisplatin, and etoposide.
Combination of formaldehyde and doxorubicin was most effective at reducing cell survival by 31-fold–39-fold (in wild type cells) relative to doxorubicin and formaldehyde alone.
This effect was dose dependent on doxorubicin.
Cotreatment with formaldehyde and doxorubicin also showed increased toxicity in anthracycline-resistant strains siz1 and msh2.
The hom6 mutant also showed sensitivity to menadione with a 2.5-fold reduction in cell survival.
The potential use of a combination of aldehydes and cytotoxic drugs could potentially lead to applications intended to enhance anthracycline-based therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miles, Jana S.& Sojourner, Samantha J.& Whitmore, Aurellia M.& Freeny, Devon& Darling-Reed, Selina& Flores-Rozas, Hernan. 2018. Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126999
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miles, Jana S.…[et al.]. Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1126999
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miles, Jana S.& Sojourner, Samantha J.& Whitmore, Aurellia M.& Freeny, Devon& Darling-Reed, Selina& Flores-Rozas, Hernan. Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1126999
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126999
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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