Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status
المؤلفون المشاركون
Kraemer-Aguiar, Luiz Guilherme
Maranhão, Priscila Alves
de Souza, Maria das Graças Coelho
Panazzolo, Diogo Guarnieri
Bouskela, Eliete
Nogueira Neto, José Firmino
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Frequently, ingestion of lipids exceeds our daily requirements and constantly exposes humans to circulating lipid overload which may lead to endothelial dysfunction (ED), the earliest marker of atherosclerosis.
Nailfold videocapillaroscopy (NVC) technique can detect ED on microcirculation.
Using NVC, we aimed to demonstrate if metabolic alterations evoked by high-fat meals can act differently on microvascular endothelial reactivity in lean and women with obesity.
Methods.
Women, aged between 19 and 40 years, were allocated to control group (CG) and with obesity group (OBG) and were subjected to blood analysis for determination of glucose, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) and NVC evaluation at fasting and 30, 60, 120, and 180-min after high-fat meal ingestion.
NVC technique evaluated microvascular reactivity through the following variables: red blood cell velocity (RBCV) at rest and after 1-min ischemia (maximal red blood cell velocity, RBCVmax) and time taken to reach it (TRBCVmax).
A P value ≤0.05 was considered significant.
Results.
High-fat meal promoted a two-phase response in both groups: one until 60-min, associated with glucose and insulin levels, and the other after 120-min, associated with TG levels.
Significant differences between groups were observed concerning insulin and HDL-c concentrations only at fasting and TC, TG, and LDL-c levels in all-time points.
Regarding microvascular reactivity, RBCV, RBCVmax, and TRBCVmax were significantly different in OBG at 30-min compared to baseline.
RBCVmax and TRBCVmax were significantly different in CG at 30-min and 60-min comparing to fasting.
In all-time points, OBG presented RBCV, RBCVmax , and TRBCVmax significantly different in comparison to CG.
Conclusion.
High-fat meal worsened ED on microcirculation in women with obesity and induced impairment of endothelial function in lean ones, reinforcing the association between high-fat meal and atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maranhão, Priscila Alves& de Souza, Maria das Graças Coelho& Panazzolo, Diogo Guarnieri& Nogueira Neto, José Firmino& Bouskela, Eliete& Kraemer-Aguiar, Luiz Guilherme. 2018. Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maranhão, Priscila Alves…[et al.]. Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maranhão, Priscila Alves& de Souza, Maria das Graças Coelho& Panazzolo, Diogo Guarnieri& Nogueira Neto, José Firmino& Bouskela, Eliete& Kraemer-Aguiar, Luiz Guilherme. Metabolic Changes Induced by High-Fat Meal Evoke Different Microvascular Responses in Accordance with Adiposity Status. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر