Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease
المؤلفون المشاركون
Yeh, Hseng-Long
Kuo, Li-Tang
Sung, Fung-Chang
Yeh, Chih-Ching
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Reactive oxygen species (ROS) been cited as one of the major causes of atherosclerosis and coronary artery disease which are possible agents inducing DNA damage.
Manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase-1 (GPx1) have evolved to address primary defense against free radical mediated damage in mitochondria.
The aim of this study was to delineate the association of MnSOD, CAT, and GPx1 polymorphisms and risk of CAD in Taiwan.
Methods.
We conducted a case-control study with 657 participants recruited at a medical center.
All subjects were evaluated by noninvasive stress test and then quantitative coronary angiography to confirm the diagnosis of CAD.
447 CAD cases were defined as >50% stenosis of coronary artery and 210 controls were stenosed below 50%.
Polymorphisms of MnSOD (Val16Ala), CAT (C-262T), and GPx1 (Pro198Leu) genes were determined by polymerase chain reaction methods.
Multivariate logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs).
Results.
The MnSOD Val/Ala+Ala/Ala genotype was significantly associated with an increased risk of CAD compared to the Val/Val genotype (OR = 1.86, 95% CI = 1.15-3.01).
This polymorphism was also associated with the severity of CAD of single and two vessel diseases.
The corresponding ORs were 2.31 (95% CI = 1.32-4.03) and 1.92 (95% CI = 1.02-3.61), respectively.
Among cigarette smokers, the harmful genetic effect of MnSOD Ala allele on CAD risk was much higher (OR = 2.23, 95% CI = 1.02-4.88).
However, the interaction between MnSOD genotype and cigarette smoking on CAD risk was not significant.
No significant association between CAT and GPx1 polymorphisms and CAD risk was observed.
Conclusion.
Our results suggest that MnSOD polymorphism is an independent risk factor for susceptibility to CAD in the Chinese population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yeh, Hseng-Long& Kuo, Li-Tang& Sung, Fung-Chang& Yeh, Chih-Ching. 2018. Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127085
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yeh, Hseng-Long…[et al.]. Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127085
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yeh, Hseng-Long& Kuo, Li-Tang& Sung, Fung-Chang& Yeh, Chih-Ching. Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127085
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127085
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر