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The Effect of Butyrate-Supplemented Parenteral Nutrition on Intestinal Defence Mechanisms and the Parenteral Nutrition-Induced Shift in the Gut Microbiota in the Rat Model
المؤلفون المشاركون
Dankova, Helena
Jirsova, Zuzana
Heczkova, Marie
Malinska, Hana
Videnska, Petra
Vespalcova, Hana
Micenkova, Lenka
Bartonova, Lenka
Lodererova, Alena
Prefertusová, Lucia
Sekerkova, Alena
Hradecky, Jaromir
Sticova, Eva
Cahova, Monika
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Butyrate produced by the intestinal microbiota is essential for proper functioning of the intestinal immune system.
Total dependence on parenteral nutrition (PN) is associated with numerous adverse effects, including severe microbial dysbiosis and loss of important butyrate producers.
We hypothesised that a lack of butyrate produced by the gut microbiota may be compensated by its supplementation in PN mixtures.
We tested whether i.v.
butyrate administration would (a) positively modulate intestinal defence mechanisms and (b) counteract PN-induced dysbiosis.
Male Wistar rats were randomised to chow, PN, and PN supplemented with 9 mM butyrate (PN+But) for 12 days.
Antimicrobial peptides, mucins, tight junction proteins, and cytokine expression were assessed by RT-qPCR.
T-cell subpopulations in mesenteric lymph nodes (MLN) were analysed by flow cytometry.
Microbiota composition was assessed in caecum content.
Butyrate supplementation resulted in increased expression of tight junction proteins (ZO-1, claudin-7, E-cadherin), antimicrobial peptides (Defa 8, Rd5, RegIIIγ), and lysozyme in the ileal mucosa.
Butyrate partially alleviated PN-induced intestinal barrier impairment and normalised IL-4, IL-10, and IgA mRNA expression.
PN administration was associated with an increase in Tregs in MLN, which was normalised by butyrate.
Butyrate increased the total number of CD4+ and decreased a relative amount of CD8+ memory T cells in MLN.
Lack of enteral nutrition and PN administration led to a shift in caecal microbiota composition.
Butyrate did not reverse the altered expression of most taxa but did influence the abundance of some potentially beneficial/pathogenic genera, which might contribute to its overall beneficial effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jirsova, Zuzana& Heczkova, Marie& Dankova, Helena& Malinska, Hana& Videnska, Petra& Vespalcova, Hana…[et al.]. 2019. The Effect of Butyrate-Supplemented Parenteral Nutrition on Intestinal Defence Mechanisms and the Parenteral Nutrition-Induced Shift in the Gut Microbiota in the Rat Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1127098
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jirsova, Zuzana…[et al.]. The Effect of Butyrate-Supplemented Parenteral Nutrition on Intestinal Defence Mechanisms and the Parenteral Nutrition-Induced Shift in the Gut Microbiota in the Rat Model. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1127098
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jirsova, Zuzana& Heczkova, Marie& Dankova, Helena& Malinska, Hana& Videnska, Petra& Vespalcova, Hana…[et al.]. The Effect of Butyrate-Supplemented Parenteral Nutrition on Intestinal Defence Mechanisms and the Parenteral Nutrition-Induced Shift in the Gut Microbiota in the Rat Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1127098
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127098
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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