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First Description of Macrolide-Resistant Mycoplasma pneumoniae in Adults with Community-Acquired Pneumonia in Italy
المؤلفون المشاركون
Martinelli, Domenico
Prato, Rosa
Chironna, Maria
Mallamaci, Rosanna
Loconsole, Daniela
De Robertis, Anna Lisa
Morea, Anna
Quarto, Michele
Sallustio, Anna
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia (CAP).
This cross-sectional study aimed to determine the prevalence of macrolide-resistant M.
pneumoniae strains in a convenience series of 234 adult hospitalised and nonhospitalised subjects with a diagnosis of CAP in January 2013 to April 2015 in South Italy.
Methods.
Respiratory samples were subjected to real-time PCR.
In M.
pneumoniae-positive samples, domain V of 23S rRNA was sequenced to detect resistance-conferring point mutations.
P1 major adhesion protein typing and multiple loci variable-number tandem repeat analysis (MLVA) were also performed.
Results.
Of the 234 samples, 15 (6.4%) were positive for M.
pneumoniae.
Three of these had a macrolide-resistant genotype: two and one had A2063G and A2064G mutations, respectively.
Fourteen of the 15 strains were subtyped: half had subtype 1 and half had subtype 2.
Eight strains underwent MLVA profiling: one each had the J, A, and Z type.
The remainder was unclassifiable.
Conclusions.
This novel discovery of macrolide-resistant M.
pneumoniae strains in adults with CAP in Italy suggests that there may be increasing circulation of these strains in the population.
To facilitate rapid optimization of the antibiotic strategy in Italy, macrolide resistance should be monitored by a surveillance system that is based on molecular methods.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Loconsole, Daniela& De Robertis, Anna Lisa& Mallamaci, Rosanna& Sallustio, Anna& Morea, Anna& Prato, Rosa…[et al.]. 2019. First Description of Macrolide-Resistant Mycoplasma pneumoniae in Adults with Community-Acquired Pneumonia in Italy. BioMed Research International،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1127154
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Loconsole, Daniela…[et al.]. First Description of Macrolide-Resistant Mycoplasma pneumoniae in Adults with Community-Acquired Pneumonia in Italy. BioMed Research International No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1127154
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Loconsole, Daniela& De Robertis, Anna Lisa& Mallamaci, Rosanna& Sallustio, Anna& Morea, Anna& Prato, Rosa…[et al.]. First Description of Macrolide-Resistant Mycoplasma pneumoniae in Adults with Community-Acquired Pneumonia in Italy. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1127154
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127154
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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