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Identification of Differentially Expressed miRNAs and mRNAs in Vestibular Schwannoma by Integrated Analysis
المؤلفون المشاركون
Lei, Yanhua
Guo, Ping
Li, Xiuguo
Zhang, Yuanyuan
Du, Ting
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Vestibular schwannoma (VS) is benign, slow-growing brain tumor that negatively impacts patient quality of life, which may cause even death.
This study aimed to explore key genes and microRNAs (miRNAs) associated with VS.
Methods.
The mRNA and miRNA expression profiles of VS downloaded from Gene Expression Omnibus (GEO) database were included in this study to perform an integrated analysis.
The differentially expressed mRNAs (DEmRNAs) and miRNAs (DEmiRNAs) were identified.
Then, functional annotation and protein-protein interaction networks (PPI) of DEmRNAs were constructed.
DEmiRNA-target DEmRNAs analysis and functional annotation of DEmiRNA-target DEmRNAs were performed.
Results.
A total of 2627 DEmRNAs (1194 upregulated and 1433 downregulated DEmRNAs) and 21 DEmiRNAs (12 upregulated and 9 downregulated DEmiRNAs) were identified.
ISG15, TLE1, and XPC were three hub proteins of VS-specific PPI network.
A total of 2970 DEmiRNAs-DEmRNAs pairs were obtained.
Among which, hsa-miR-181a-5p, hsa-miR-106-5p, and hsa-miR-34a-5p were the top three DEmiRNAs that covered most DEmRNAs.
The functional annotation of DEmiRNA-target DEmRNAs revealed that the DEmiRNA-target DEmRNAs were significantly enriched in cGMP-PKG signaling pathway, adrenergic signaling in cardiomyocytes, and pathways in cancer.
Conclusion.
The results of this present study may provide a comprehensive understanding for the roles of DEmRNAs and DEmiRNAs in the pathogenesis of VS and developing potential biomarkers of VS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lei, Yanhua& Guo, Ping& Li, Xiuguo& Zhang, Yuanyuan& Du, Ting. 2019. Identification of Differentially Expressed miRNAs and mRNAs in Vestibular Schwannoma by Integrated Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127191
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lei, Yanhua…[et al.]. Identification of Differentially Expressed miRNAs and mRNAs in Vestibular Schwannoma by Integrated Analysis. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1127191
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lei, Yanhua& Guo, Ping& Li, Xiuguo& Zhang, Yuanyuan& Du, Ting. Identification of Differentially Expressed miRNAs and mRNAs in Vestibular Schwannoma by Integrated Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127191
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127191
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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