Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat
المؤلفون المشاركون
Lee, Simon Ming-Yuen
Leung, George Pak-Heng
Feng, Yu
Chen, Yan
Yang, Binrui
Lan, Qingping
Wang, Tao
Ren, Zhitao
Choi, I. Cheong
Yan, Fenggen
Chen, Dacan
Yu, Hon Ho
Cui, Guozhen
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In parallel with the prevalence metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in most countries.
It features a constellation of simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even hepatocellular carcinoma.
There are no approved drugs for effective management of NAFLD and NASH.
Jianpi Huoxue formula (JPHX) mainly consists of Atractylodes macrocephal (Baizhu), Salvia miltiorrhiza (Danshen), Rasux Paeonia Alba (Baishao), Rhizoma Alismatis (Zexie), and Fructus Schisandrae Chinensis (Wuweizi), which may have beneficial effects on NAFLD.
The aim of the study was to identify the effect of JPHX on NAFLD.
A NAFLD model was induced by methionine-choline-deficient food (MCD) in Wistar rats and orally administered with simultaneous JPHX, once a day for 8 weeks.
Hepatocellular injury, lipid profile, inflammation, fibrosis, and apoptosis were evaluated.
The results showed that JPHX significantly decreased the abnormal serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared with the MCD model (P<0.05).
Furthermore, JPHX protected MCD diet-fed rats from accumulation of hepatic triglycerides (TG) and total cholesterol (TC).
Histological examination demonstrated that JPHX noticeably normalized the NAFLD activity score (NAS).
Moreover, JPHX ameliorated liver inflammation by decreasing TNF-α levels and reduced collagen and matrix metalloproteinases in MCD diet-fed rats.
In addition, JPHX prevented rats from MCD-induced cellular apoptosis, as suggested by TUNEL staining, and suppressed the activation of caspase 3 and 7 proteins.
JPHX also inhibited the phosphorylation of JNK.
In conclusion, JPHX exhibited a hepatoprotective effect against NAFLD in an MCD experimental model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feng, Yu& Chen, Yan& Yang, Binrui& Lan, Qingping& Wang, Tao& Cui, Guozhen…[et al.]. 2019. Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127311
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Yu…[et al.]. Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1127311
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feng, Yu& Chen, Yan& Yang, Binrui& Lan, Qingping& Wang, Tao& Cui, Guozhen…[et al.]. Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127311
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127311
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر