Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose

المؤلفون المشاركون

Yu, Pei
Saijun, Zhou
Xin, Li
Jie, Wang
Shumin, Xiao
Shuaihui, Liu

المصدر

BioMed Research International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-07-18

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

VEGF-NO axis uncoupling is an important pathogenesis for DN.

Reduced β2GPI could play a part in VEGF signaling pathway and has a protective effect on diabetic vascular disease.

This study investigates the effect of reduced β2GPI on glomerular mesangial cells VEGF-NO axis uncoupling induced by high glucose.

Compared to control group, glomerular mesangial cell line HBZY-1 cells treated with high glucose expressed higher levels of VEGF mRNA and protein and produced more ROS but less NO.

The related proteins related to VEGF-NO axis were assayed.

High glucose could significantly increase the expression of the level of VEGFR2 and obviously increase phosphorylation of Akt and eNOS but significantly decrease the expression of GTP cyclohydrolase 1 (GCH-1), reducing the production of eNOS dimer.

Both β2GPI and reduced β2GPI partly reverse these effects caused by high glucose.

Reduced β2GPI had stronger effect than β2GPI.

GCH-1 is the speed limit of tetrahydrobiopterin (BH4) synthesis enzyme.

As the key part of eNOS cofactors, BH4 could partly restore eNOS dimer induced by high glucose.

Our results indicated that high glucose could interfere with eNOS dimer formation.

β2GPI and reduced β2GPI can partly reverse the VEGF-NO axis uncoupling by restoring the GCH-1 expression level and then promote eNOS dimer formation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Saijun, Zhou& Xin, Li& Jie, Wang& Shumin, Xiao& Shuaihui, Liu& Yu, Pei. 2018. Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127349

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Saijun, Zhou…[et al.]. Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1127349

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Saijun, Zhou& Xin, Li& Jie, Wang& Shumin, Xiao& Shuaihui, Liu& Yu, Pei. Reduced β2GPI Inhibiting Glomerular Mesangial Cells VEGF-NO Axis Uncoupling Induced by High Glucose. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1127349

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1127349