Synergistic Activity of ColistinFosfomycin Combination against Carbapenemase-Producing Klebsiella pneumoniae in an In Vitro PharmacokineticPharmacodynamic Model
المؤلفون المشاركون
Wang, Rui
Bai, Yan
Cai, Yun
Wang, Jin
He, Ji-tong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Carbapenemase-producing Klebsiella pneumoniae is globally recognized as one of the greatest threats to public health, and combination therapy may be the chemotherapeutic option.
In the present study, we aimed to evaluate the antibacterial effects of colistin/fosfomycin combination against carbapenemase-producing K.
pneumoniae.
The antibacterial effects were determined in a one-compartment in vitro pharmacokinetic model over a period of 24 h.
The initial inoculum was 108 CFU/mL.
Low, medium, and high C m a x values of colistin at 0.5, 2, and 5 mg/L as well as C m a x of fosfomycin at 100 mg/L were simulated in the model.
Doses of both colistin and fosfomycin were given every 8 h until 24 h.
For the colistin- and fosfomycin-susceptible isolate KP47, three combination regimens showed greater killing effect compared with colistin monotherapy.
The greatest killing effect was observed in combination regimen containing 5 mg/L colistin.
For colistin-heteroresistant and fosfomycin-susceptible isolate KP79, combination regimen containing low dose colistin (0.5 mg/L) showed no synergistic or additive effects.
However, combination regimens containing 2 and 5 mg/L colistin maintained the bactericidal effect until 24 h compared with colistin monotherapy.
For colistin-heteroresistant and fosfomycin-resistant isolates KP42 and KP11, bactericidal activity was barely enhanced by combination regimens.
Moreover, combination regimen containing 5 mg/L colistin could only prevent the emergence of colistin-resistant subpopulation in colistin and fosfomycin-susceptible isolate.
It is necessary to know the resistant patterns of the K.
pneumoniae before using combination of colistin and fosfomycin in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jin& He, Ji-tong& Bai, Yan& Wang, Rui& Cai, Yun. 2018. Synergistic Activity of ColistinFosfomycin Combination against Carbapenemase-Producing Klebsiella pneumoniae in an In Vitro PharmacokineticPharmacodynamic Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127466
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jin…[et al.]. Synergistic Activity of ColistinFosfomycin Combination against Carbapenemase-Producing Klebsiella pneumoniae in an In Vitro PharmacokineticPharmacodynamic Model. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1127466
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jin& He, Ji-tong& Bai, Yan& Wang, Rui& Cai, Yun. Synergistic Activity of ColistinFosfomycin Combination against Carbapenemase-Producing Klebsiella pneumoniae in an In Vitro PharmacokineticPharmacodynamic Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1127466
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127466
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر