Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice
المؤلفون المشاركون
Zigangirova, Naylia A.
Kapotina, Lidia N.
Gintsburg, Alexandr L.
Kobets, Natalia V.
Zayakin, Egor S.
Luyksaar, Sergei I.
Sheremet, Anna B.
Nesterenko, Ludmila N.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Pseudomonas aeruginosa is a cause of high mortality in burn, immunocompromised, and surgery patients.
High incidence of antibiotic resistance in this pathogen makes the existent therapy inefficient.
Type three secretion system (T3SS) is a leading virulence system of P.
aeruginosa that actively suppresses host resistance and enhances the severity of infection.
Innovative therapeutic strategies aiming at inhibition of type three secretion system of P.
aeruginosa are highly attractive, as they may reduce the severity of clinical manifestations and improve antibacterial immune responses.
They may also represent an attractive therapy for antibiotic-resistant bacteria.
Recently our laboratory developed a new small molecule inhibitor belonging to a class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones, Fluorothiazinon (FT), that effectively suppressed T3SS in chlamydia and salmonella in vitro and in vivo.
In this study, we evaluate the activity of FT towards antibiotic-resistant clinical isolates of P.
aeruginosa expressing T3SS effectors ExoU and ExoS in an airway infection model.
We found that FT reduced mortality and bacterial loads and decrease lung pathology and systemic inflammation.
In addition, we show that FT inhibits the secretion of ExoT and ExoY, reduced bacteria cytotoxicity, and increased bacteria internalization in vitro.
Overall, FT shows a strong potential as an antibacterial therapy of antibiotic-resistant P.
aeruginosa infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sheremet, Anna B.& Zigangirova, Naylia A.& Zayakin, Egor S.& Luyksaar, Sergei I.& Kapotina, Lidia N.& Nesterenko, Ludmila N.…[et al.]. 2018. Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127527
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sheremet, Anna B.…[et al.]. Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1127527
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sheremet, Anna B.& Zigangirova, Naylia A.& Zayakin, Egor S.& Luyksaar, Sergei I.& Kapotina, Lidia N.& Nesterenko, Ludmila N.…[et al.]. Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1127527
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127527
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر