Correlation between the Expression of PD-L1 and Clinicopathological Features in Patients with Thymic Epithelial Tumors
المؤلفون المشاركون
Chen, Guo-Rong
Chen, Yanmei
Zhang, Yuping
Chai, Xiaoling
Gao, Jianfang
Zhang, Weifen
Zhang, Yunxiang
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The incidence of thymic epithelial tumors (TETs) in the Chinese population was much higher than that in the North American population.
In clinical treatment, the prognosis of benign tumors after surgical resection was significantly better than that of malignant tumors.
Currently, the commonly used clinical indicators for TET staging included Masaoka staging and WHO (2015) pathological criteria; however, the distinction between the benign and malignant tumors and diagnosis is yet to be explored.
The current study demonstrated that the expression of PD-L1 in tumor cells was correlated with the degree of TET malignancy.
The quantitative analysis of PD-L1 expression in 70 cases of TET tumor samples revealed that the positive rate of PD-L1 expression in types A, AB, B1, and B2 of thymoma (40 cases) was 37.5% (15/40), which was significantly lower than that in type B3 thymoma and thymic carcinoma (76.67%, 30 cases, 23/30) as demonstrated by chi-square test (P<0.05).
In addition, the two methods were analyzed for the quantitative detection of PD-L1 expression.
The results from the estimation of transcriptional RNA expression and quantitative protein immunohistochemistry were consistent (r=0.745).
Furthermore, we also analyzed PD-L1 expression level in different types of TETs from TCGA database and observed that higher PD-L1 expression was in thymic carcinoma than in thymoma.
Therefore, it could be concluded that PD-L1 expression in TET cells was correlated with the degree of malignancy, whereas the estimation of PD-L1 expression was potentially applicable in the clinical staging of TETs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yanmei& Zhang, Yuping& Chai, Xiaoling& Gao, Jianfang& Chen, Guo-Rong& Zhang, Weifen…[et al.]. 2018. Correlation between the Expression of PD-L1 and Clinicopathological Features in Patients with Thymic Epithelial Tumors. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127559
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yanmei…[et al.]. Correlation between the Expression of PD-L1 and Clinicopathological Features in Patients with Thymic Epithelial Tumors. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1127559
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yanmei& Zhang, Yuping& Chai, Xiaoling& Gao, Jianfang& Chen, Guo-Rong& Zhang, Weifen…[et al.]. Correlation between the Expression of PD-L1 and Clinicopathological Features in Patients with Thymic Epithelial Tumors. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127559
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127559
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر