Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development
المؤلفون المشاركون
Hamamah, Samir
Boumela, I.
Chebli, K.
Haouzi, Delphine
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-01
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Survival and cell death signals are crucial for mammalian embryo preimplantation development.
However, the knowledge on the molecular mechanisms underlying their regulation is still limited.
Mouse studies are widely used to understand preimplantation embryo development, but extrapolation of these results to humans is questionable.
Therefore, we wanted to analyse the global expression profiles during early mouse and human development with a special focus on genes involved in the regulation of the apoptotic and survival pathways.
We used DNA microarray technology to analyse the global gene expression profiles of preimplantation human and mouse embryos (metaphase II oocytes, embryos at the embryonic genome activation stage, and blastocysts).
Components of the major apoptotic and survival signalling pathways were expressed during early human and mouse embryonic development; however, most expression profiles were species-specific.
Particularly, the expression of genes encoding components and regulators of the apoptotic machinery were extremely stable in mouse embryos at all analysed stages, while it was more stage-specific in human embryos.
CASP3, CASP9, and AIF were the only apoptosis-related genes expressed in both species and at all studied stages.
Moreover, numerous transcripts related to the apoptotic and survival pathway were reported for the first time such as CASP6 and IL1RAPL1 that were specific to MII oocytes; CASP2, ENDOG, and GFER to blastocysts in human.
These findings open new perspectives for the characterization and understanding of the survival and apoptotic signalling pathways that control early human and mouse embryonic development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haouzi, Delphine& Boumela, I.& Chebli, K.& Hamamah, Samir. 2018. Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1127610
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haouzi, Delphine…[et al.]. Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1127610
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haouzi, Delphine& Boumela, I.& Chebli, K.& Hamamah, Samir. Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1127610
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127610
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر