Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer
المؤلفون المشاركون
Shi, Linsen
Song, Hu
Wu, Zhaoying
Yang, Lin
Shi, Peicong
Yang, Ting
Fan, Ruizhi
Jiang, Tao
Song, Jun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Programmed cell death ligand 1 (PD-L1) is a key inhibitor to the immune response by binding to the specific receptor PD-1.
Adenosine receptor 2 (A2aR) can play an immunosuppressive role in tumor microenvironment by binding to its ligand adenosine (ADO).
However, the expression of these two markers has been rarely studied in colorectal cancer simultaneously.
Materials and Methods.
We, respectively, collected tumor and adjacent nontumor tissue specimens of 204 patients with colorectal cancer.
The expressions of PD-L1 and A2aR were detected by immunohistochemistry.
The association among their expressions with clinicopathological characteristics and prognostic parameters were analyzed as well.
Results.
The expressions of PD-L1 and A2aR in tumor tissues were both higher than those in matched adjacent nontumor tissues.
PD-L1 expression was significantly correlated with lymph node metastasis and tumor TNM stage.
A2aR expression was significantly correlated with tumor size, depth of tumor invasion, and TNM stage.
Univariate analysis showed that the high expressions of PD-L1 and A2aR were inversely correlated with the overall survival, respectively.
Multivariate analysis further confirmed that both of them were independent prognostic markers for patients.
Conclusion.
The results of this study suggested that the high expressions of PD-L1 and A2aR were associated with a poor prognosis of colorectal cancer.
Coinhibition of these two proteins may be a new breakthrough in the treatment of this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Zhaoying& Yang, Lin& Shi, Linsen& Song, Hu& Shi, Peicong& Yang, Ting…[et al.]. 2019. Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Zhaoying…[et al.]. Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1127662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Zhaoying& Yang, Lin& Shi, Linsen& Song, Hu& Shi, Peicong& Yang, Ting…[et al.]. Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر