Retrospective Analysis of Endocrine Dysfunctions in a Population of Adult Polytransfused Patients: Correlation of GH-IGF1 Axis Alteration with Cardiac Performance
المؤلفون المشاركون
Campo, Michela Rosaria
Farese, Anna
Correale, Michele
Berti, Giuseppe
Massa, Michela
Sorrentino, Maria Rosaria
Roberti, Grazia
Sportelli, Filomena
Cignarelli, Mauro
Lamacchia, Olga
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Endocrine complications of haemochromatosis and heart failure mostly affect morbidity and mortality in polytransfused patients.
This study analyzes endocrine dysfunctions and the impact of GH-IGF-1 axis alteration on cardiac performance in a population of 31 patients.
A retrospective study on 31 Caucasian polytransfused outpatients, 27 adults and 4 pediatric, residing in Apulia, Italy, followed from 2005 to 2016, was conducted.
Patients underwent basal and dynamic hormonal evaluation.
GHRH plus arginine test was performed in 21 patients (19 adults and 2 children).
Among them, 9 patients were affected by left ventricle diastolic dysfunction and/or atrial or ventricular dilatation (HD group) and 12 patients did not have cardiovascular disease (non-HD group).
Twenty-nine out of 31 patients (94%) had at least one endocrinopathy.
We found severe or mild GH deficit (GHD) in all HD patients versus 3 patients in the non-HD group (p=0.001).
Mean IGF-1 levels were significantly lower in the HD group than in non-HD subjects (53±30 versus 122±91 μg/L, p=0.04).
Our study confirms the need to perform a dynamic evaluation of the GH-IGF1 axis in polytransfused patients, especially when heart dysfunction emerges.
An intervention study with GH replacement therapy in a larger randomized adult population will clarify the role of GH/IGF axis on cardiovascular outcomes in this patient population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Campo, Michela Rosaria& Farese, Anna& Correale, Michele& Berti, Giuseppe& Massa, Michela& Sorrentino, Maria Rosaria…[et al.]. 2018. Retrospective Analysis of Endocrine Dysfunctions in a Population of Adult Polytransfused Patients: Correlation of GH-IGF1 Axis Alteration with Cardiac Performance. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127663
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Campo, Michela Rosaria…[et al.]. Retrospective Analysis of Endocrine Dysfunctions in a Population of Adult Polytransfused Patients: Correlation of GH-IGF1 Axis Alteration with Cardiac Performance. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1127663
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Campo, Michela Rosaria& Farese, Anna& Correale, Michele& Berti, Giuseppe& Massa, Michela& Sorrentino, Maria Rosaria…[et al.]. Retrospective Analysis of Endocrine Dysfunctions in a Population of Adult Polytransfused Patients: Correlation of GH-IGF1 Axis Alteration with Cardiac Performance. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1127663
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127663
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر