STC2 Is a Potential Prognostic Biomarker for Pancreatic Cancer and Promotes Migration and Invasion by Inducing Epithelial–Mesenchymal Transition

المؤلفون المشاركون

Lin, Chen
Sun, Lina
Huang, Shenglei
Weng, Xiangqun
Wu, Zhixian

المصدر

BioMed Research International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-07-15

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Aberrant expression of stanniocalcin 2 (STC2) is implicated in cancer development.

STC2 acts as a tumor promoter to drive some cancers.

However, its contribution to the development of pancreatic cancer remains unclear.

This study showed that the expression of STC2 was significantly upregulated in pancreatic cancer tissues.

Moreover, its expression was positively correlated with tumor size and lymph node metastasis and negatively correlated with 5-year survival rate of pancreatic cancer patients.

Additionally, the expression levels of STC2 were a novel biomarker for predicting overall survival rate after surgery.

Furthermore, overexpression of STC2 could promote the proliferation, migration, and invasion of pancreatic cancer cell lines, while knocking down of STC2 led to antiproliferation and antimetastasis activities.

Further mechanistic investigations revealed that the expression of STC2 could significantly promote the epithelial–mesenchymal transition (EMT) in pancreatic cancer cells.

These data indicated that the overexpression of STC2 in pancreatic cancer contributes to the metastasis through the promotion of EMT, suggesting that STC2 is a potential prognostic biomarker and therapeutic target for pancreatic cancer.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lin, Chen& Sun, Lina& Huang, Shenglei& Weng, Xiangqun& Wu, Zhixian. 2019. STC2 Is a Potential Prognostic Biomarker for Pancreatic Cancer and Promotes Migration and Invasion by Inducing Epithelial–Mesenchymal Transition. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127674

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lin, Chen…[et al.]. STC2 Is a Potential Prognostic Biomarker for Pancreatic Cancer and Promotes Migration and Invasion by Inducing Epithelial–Mesenchymal Transition. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127674

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lin, Chen& Sun, Lina& Huang, Shenglei& Weng, Xiangqun& Wu, Zhixian. STC2 Is a Potential Prognostic Biomarker for Pancreatic Cancer and Promotes Migration and Invasion by Inducing Epithelial–Mesenchymal Transition. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127674

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1127674