A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet
المؤلفون المشاركون
Zhu, Jie
Luo, Dan
Cao, Yan
Yang, Jian-ping
Zhu, Xiao-gang
Chang, Hong-qin
Guo, Sheng-hua
Zhou, Bing-rong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the efficacy and safety of three treatment approaches to applying Botulinum Toxin Type A (BoNTA) for crow’s Feet.
Methods.
Thirty female subjects with moderate-to-severe crow’s feet were included in this comparative in vivo study.
They were randomly divided into three groups, including the local intramuscular, intradermal microdroplet injection, and nanomicroneedle delivered with BoNTA therapy group.
After one session, evaluations were done at the time points of weeks one, four, and twelve after the treatment.
The assessments included subjective satisfaction, blinded clinical assessment, and the biophysical parameters (skin collagen content, elasticity, hydration, and sebum contents).
Results.
For dynamic wrinkles, intramuscular injection and intradermal microdroplets injection were more effective than nanomicroneedles.
For static wrinkles, nanomicroneedles and intradermal microdroplets injection were more effective.
However, the intramuscular injection had no significant effect on static wrinkles.
At one week and four weeks after the treatment, the skin elasticity, collagen content, and hydration of nanomicroneedle group and intradermal microdroplet group increased more significantly than those of the intramuscular injection group; at twelve weeks after the treatment, the skin elasticity, collagen content, and hydration of intradermal microdroplet group were higher than those of other two groups.
However we observed no statistically significant difference in sebum content between the three groups before and after the treatment.
Conclusion.
BoNTA delivered through nanomicroneedles and intradermal microdroplets injection can effectively treat crow’s feet.
This trial is registered with [2016]KY018-01, registered 16 Feb 2016.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Yan& Yang, Jian-ping& Zhu, Xiao-gang& Zhu, Jie& Chang, Hong-qin& Guo, Sheng-hua…[et al.]. 2018. A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Yan…[et al.]. A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1127790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Yan& Yang, Jian-ping& Zhu, Xiao-gang& Zhu, Jie& Chang, Hong-qin& Guo, Sheng-hua…[et al.]. A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر