Alteration of the Gut Microbiota and Its Effect on AMPKNADPH Oxidase Signaling Pathway in 2K1C Rats
المؤلفون المشاركون
Yu, Hui
Qin, Lei
Hu, Hai
Wang, Zhanli
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The purpose of this study was to evaluate the alteration of the gut microbiota and its effect on adenosine monophosphate-activated protein kinase (AMPK)/nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) signaling pathway in two-kidney one-clip (2K1C) rats.
Methods.
The 2K1C rat models were established.
The rats were randomly divided into the following 2 groups: 2K1C group and sham group.
Alterations of the gut microbiota were analyzed based on the high throughput sequencing method.
Plasma concentrations of short chain fatty acids (SCFAs) were measured by chromatography.
The protein expression of phosphorylated AMPK and acetyl-CoA carboxylase (ACC) was determined by western blotting.
NADPH oxidase activity was measured by a luminometer.
Results.
Microbial community analyses revealed that the structure and composition of the gut microbiota were significantly disrupted in 2K1C rats when compared to sham rats.
This disruption was associated with the drastic increase in relative abundance of the genera Prevotella and the decrease in SCFA-producing bacterial population.
We further confirm that SCFAs produced by the gut microbiota influence NADPH oxidase activity through AMPK.
Conclusions.
Our data implicated the important role of gut microbiota in the regulation of AMPK/NADPH oxidase signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Hui& Qin, Lei& Hu, Hai& Wang, Zhanli. 2019. Alteration of the Gut Microbiota and Its Effect on AMPKNADPH Oxidase Signaling Pathway in 2K1C Rats. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Hui…[et al.]. Alteration of the Gut Microbiota and Its Effect on AMPKNADPH Oxidase Signaling Pathway in 2K1C Rats. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1127813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Hui& Qin, Lei& Hu, Hai& Wang, Zhanli. Alteration of the Gut Microbiota and Its Effect on AMPKNADPH Oxidase Signaling Pathway in 2K1C Rats. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1127813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر