Transient Abnormalities in Masking Tuning Curve in Early Progressive Hearing Loss Mouse Model
المؤلفون المشاركون
Souchal, Marion
Labanca, Ludimila
Alves da Silva Carvalho, Sirley
Macedo de Resende, Luciana
Blavignac, Christelle
Avan, Paul
Giraudet, Fabrice
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Damage to cochlear outer hair cells (OHCs) usually affects frequency selectivity in proportion to hearing threshold increase.
However, the current clinical heuristics that attributes poor hearing performance despite near-normal auditory sensitivity to auditory neuropathy or “hidden” synaptopathy overlooks possible underlying OHC impairment.
Here, we document the part played by OHCs in influencing suprathreshold auditory performance in the presence of noise in a mouse model of progressive hair cell degeneration, the CD1 strain, at postnatal day 18–30 stages when high-frequency auditory thresholds remained near-normal.
Nonetheless, total loss of high-frequency distortion product otoacoustic emissions pointed to nonfunctioning basal OHCs.
This “discordant profile” came with a huge low-frequency shift of masking tuning curves that plot the level of interfering sound necessary to mask the response to a probe tone, against interfering frequency.
Histology revealed intense OHC hair bundle abnormalities in the basal cochlea uncharacteristically associated with OHC survival and preserved coupling with the tectorial membrane.
This pattern dismisses the superficial diagnosis of “hidden” neuropathy while underpinning a disorganization of cochlear frequency mapping with optimistic high-frequency auditory thresholds perhaps because responses to high frequencies are apically shifted.
The audiometric advantage of frequency transposition is offset by enhanced masking by low-frequency sounds, a finding essential for guiding rehabilitation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Souchal, Marion& Labanca, Ludimila& Alves da Silva Carvalho, Sirley& Macedo de Resende, Luciana& Blavignac, Christelle& Avan, Paul…[et al.]. 2018. Transient Abnormalities in Masking Tuning Curve in Early Progressive Hearing Loss Mouse Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1127814
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Souchal, Marion…[et al.]. Transient Abnormalities in Masking Tuning Curve in Early Progressive Hearing Loss Mouse Model. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1127814
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Souchal, Marion& Labanca, Ludimila& Alves da Silva Carvalho, Sirley& Macedo de Resende, Luciana& Blavignac, Christelle& Avan, Paul…[et al.]. Transient Abnormalities in Masking Tuning Curve in Early Progressive Hearing Loss Mouse Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1127814
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127814
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر