Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro
المؤلفون المشاركون
Braga, Gilberto Úbida Leite
Bulhões Portapilla, Gisele
Pereira, Luiz Miguel
Bronzon da Costa, Cássia Mariana
Voltarelli Providello, Maiara
Sampaio Oliveira, Pedro Alexandre
Goulart, Amanda
Ferreira Anchieta, Naira
Wainwright, Mark
de Albuquerque, Sérgio
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Chagas disease is a tropical illness caused by the protozoan Trypanosoma cruzi.
The disease affects populations of the Americas and has been spread to other continents due to the migration process.
The disease is partially controlled by two drugs, Benznidazole and Nifurtimox.
These molecules are active in the acute phase of the infection but are usually ineffective during the symptomatic chronic phase.
Several research groups have developed novel candidates to control Chagas disease; however, no novel commercial formulation is available.
In this article, we described the anti-T.
cruzi effects of phenothiazinium dyes in amastigote and trypomastigote forms of the parasite.
Methylene Blue, New Methylene Blue, Toluidine Blue O, and 1,9-Dimethyl Methylene Blue inhibited the parasite proliferation at nanomolar concentrations and also demonstrated low toxicity in host cells.
Moreover, combinations of phenothiazinium dyes indicated a synergic pattern against amastigotes compared to the Benznidazole counterparts.
Phenothiazinium dyes levels of reactive oxygen species (ROS) and decreased the mitochondrial potential in trypomastigotes, indicating the mechanism of action of the dyes in T.
cruzi.
Our article offers a basis for future strategies for the control of Chagas disease using low-cost formulations, an important point for endemic underdeveloped regions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bulhões Portapilla, Gisele& Pereira, Luiz Miguel& Bronzon da Costa, Cássia Mariana& Voltarelli Providello, Maiara& Sampaio Oliveira, Pedro Alexandre& Goulart, Amanda…[et al.]. 2019. Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bulhões Portapilla, Gisele…[et al.]. Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bulhões Portapilla, Gisele& Pereira, Luiz Miguel& Bronzon da Costa, Cássia Mariana& Voltarelli Providello, Maiara& Sampaio Oliveira, Pedro Alexandre& Goulart, Amanda…[et al.]. Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر