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Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies
المؤلفون المشاركون
Petrovic, Milan
Jelovac, Drago B.
Antic, Svetlana
Antunovic, Marija
Lukic, Nikola
Sabani, Melvil
Mudrak, Joerg
Jezdic, Zoran
Pucar, Ana
Stefanovic, Aleksandar
Kuzmanovic, Cedomir
Nikolic, Danilo
Konstantinovic, Vitomir
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome.
Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018.
Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis.
Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality.
MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively.
MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously.
Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively.
Mandible was affected in 23 (72%) patients.
MRONJ was treated in our department by conservative and surgical modality.
In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group.
The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome.
Comprehensive treatment protocol and further randomized studies are necessary for further improvements.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Petrovic, Milan& Jelovac, Drago B.& Antic, Svetlana& Antunovic, Marija& Lukic, Nikola& Sabani, Melvil…[et al.]. 2019. Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Petrovic, Milan…[et al.]. Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1127877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Petrovic, Milan& Jelovac, Drago B.& Antic, Svetlana& Antunovic, Marija& Lukic, Nikola& Sabani, Melvil…[et al.]. Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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