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Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications
المؤلفون المشاركون
Lai, Jimmy S. M.
Kwok, Sum Sum
Shih, Kendrick Co
Fu, Lin
Chan, Yau Kei
Pan, Weihua
Nie, Li
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Retinal ganglion cell (RGC) death is the central and irreversible endpoint of optic neuropathies.
Current management of optic neuropathies and glaucoma focuses on intraocular pressure-lowering treatment which is insufficient.
As such, patients are effectively condemned to irreversible visual impairment.
This review summarizes experimental treatments targeting RGCs over the last decade.
In particular, we examine the various treatment modalities and determine their viability and limitations in translation to clinical practice.
Experimental RGC treatment can be divided into (1) cell replacement therapy, (2) neuroprotection, and (3) gene therapy.
For cell replacement therapy, difficulties remain in successfully integrating transplanted RGCs from various sources into the complex neural network of the human retina.
However, there is significant potential for achieving full visual restoration with this technique.
Neuroprotective strategies, in the form of pharmacological agents, nutritional supplementation, and neurotrophic factors, are viable strategies with encouraging results from preliminary noncomparative interventional case series.
It is important to note, however, that most published studies are focused on glaucoma, with few treating optic neuropathies of other etiologies.
Gene therapy, through the use of viral vectors, has shown promising results in clinical trials, particularly for diseases with specific genetic mutations like Leber’s hereditary optic neuropathy.
This treatment technique can be further extended to nonhereditary diseases, through transfer of genes promoting cell survival and neuroprotection.
Crucially though, for gene therapy, teratogenicity remains a significant issue in translation to clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Lin& Kwok, Sum Sum& Chan, Yau Kei& Lai, Jimmy S. M.& Pan, Weihua& Nie, Li…[et al.]. 2019. Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Lin…[et al.]. Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1127898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Lin& Kwok, Sum Sum& Chan, Yau Kei& Lai, Jimmy S. M.& Pan, Weihua& Nie, Li…[et al.]. Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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