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Smooth Muscle Progenitor Cells Preserve the Erectile Function by Reducing Corporal Smooth Muscle Cell Apoptosis after Bilateral Cavernous Nerve Crush Injury in Rats
المؤلفون المشاركون
Liao, ChunHou
Wu, Yi-No
Chen, Kuo-Chiang
Chiang, Han-Sun
Liu, Chien-Liang
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Radical prostatectomy causes erectile dysfunction (ED) and irreversible morphologic changes, including induction of endothelial and smooth muscle cell (SMC) apoptosis in the corpus cavernosum (CC).
The injection of smooth muscle progenitor cells (SPCs) thickens the vascular intima and has demonstrated therapeutic benefit in cardiovascular disease animal.
Herein, we investigated the effect of SPCs on the recovery of erectile function (EF) in rat models with bilateral cavernous nerve (CN) injury.
Twenty-four male Sprague-Dawley rats were randomized into sham, vehicle only, or SPC treatment groups.
Rats in the SPC treatment and vehicle groups were subjected to bilateral CN injury before intracavernosal injection.
Intracavernosal injections of SPCs increased all EF parameters at day 28 after injury and simultaneously reduced apoptosis of the SMCs.
Ultrastructural analysis revealed that SPCs maintained the integrity of the CC by preserving the structure of the adherens junctions.
Tracking transplanted SPCs labeled with EdU showed that transplanted SPCs remained in the CC 28 days after treatment.
Intracavernosal SPC injection restored EF after bilateral CN injury by reducing SMC apoptosis, which favored the maintenance of the structure of adherens junctions and regulated the stability of corporal vessels.
These findings demonstrate the therapeutic potential of SPCs for treating ED in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yi-No& Chen, Kuo-Chiang& Liao, ChunHou& Liu, Chien-Liang& Chiang, Han-Sun. 2019. Smooth Muscle Progenitor Cells Preserve the Erectile Function by Reducing Corporal Smooth Muscle Cell Apoptosis after Bilateral Cavernous Nerve Crush Injury in Rats. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yi-No…[et al.]. Smooth Muscle Progenitor Cells Preserve the Erectile Function by Reducing Corporal Smooth Muscle Cell Apoptosis after Bilateral Cavernous Nerve Crush Injury in Rats. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1127939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yi-No& Chen, Kuo-Chiang& Liao, ChunHou& Liu, Chien-Liang& Chiang, Han-Sun. Smooth Muscle Progenitor Cells Preserve the Erectile Function by Reducing Corporal Smooth Muscle Cell Apoptosis after Bilateral Cavernous Nerve Crush Injury in Rats. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1127939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127939
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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