Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding”
المؤلف
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-2، 2ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-19
دولة النشر
مصر
عدد الصفحات
2
التخصصات الرئيسية
الملخص EN
It was a pleasure to read the paper “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding” by Rai and colleagues [1] in the recent issue of BioMed Research International.
It is an important topic and by using magnetic resonance imaging (MRI) to characterize right ventricular (RV) performance it adds to previous studies on the same subject [2–6].
The authors conclude that both sildenafil and riociguat prevent RV failure in mice subjected to pulmonary artery banding (PAB) based on improvement in stroke volume (SV) and ejection fraction (EF).
It does however seem that there is a miscalculation in the EF and SV parameters reported by the authors.
By using the parameters reported by the authors to recalculate, SV is reduced and the improvement in EF is less pronounced in riociguat treated animals which would change the interpretation of the results.
Stroke volume was calculated based on MRI derived parameters as SV=EDV-ESV and EF was calculated as EF=SV/EDV.
EDV is reported as 79.6 μl (placebo), 59.9 μl (sildenafil), and 44.0 μl (riociguat).
ESV is reported as 54.7 μl (placebo), 33.9 μl (sildenafil), and 24.7 μl (riociguat).
This would yield an EF of 31% (placebo), 43% (sildenafil), and 44% (riociguat) and a SV of 24.9 μl (placebo), 26 μl (sildenafil), and 19.3 μl (riociguat).
The authors report EF of 30% (placebo), 45% (sildenafil), and 58% (riociguat) and a SV of 24.2 (placebo), 25.9 (sildenafil), and 28.5 μl (riociguat).
This discrepancy should be clarified, as it could potentially change the interpretation and the conclusion of the present study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Andersen, Asger. 2018. Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding”. BioMed Research International،Vol. 2018, no. 2018, pp.1-2.
https://search.emarefa.net/detail/BIM-1128018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Andersen, Asger. Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding”. BioMed Research International No. 2018 (2018), pp.1-2.
https://search.emarefa.net/detail/BIM-1128018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Andersen, Asger. Comment on “Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding”. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-2.
https://search.emarefa.net/detail/BIM-1128018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر