A Comparative Genomic and Phylogenetic Analysis of the Origin and Evolution of the CCN Gene Family
المؤلفون المشاركون
Hu, Kuan
Tao, Yiming
Li, Juanni
Liu, Zhuang
Zhu, Xinyan
Wang, Zhiming
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
CCN gene family members have recently been identified as multifunctional regulators involved in diverse biological functions, especially in vascular and skeletal development.
In the present study, a comparative genomic and phylogenetic analysis was performed to show the similarities and differences in structure and function of CCNs from different organisms and to reveal their potential evolutionary relationship.
First, CCN homologs of metazoans from different species were identified.
Then we made multiple sequence alignments, MEME analysis, and functional sites prediction, which show the highly conserved structural features among CCN metazoans.
The phylogenetic tree was further established, and thus CCNs were found undergoing extensive lineage-specific duplication events and lineage-specific expansion during the evolutionary process.
Besides, comparative analysis about the genomic organization and chromosomal CCN gene surrounding indicated a clear orthologous relationship among these species counterparts.
At last, based on these research results above, a potential evolutionary scenario was generated to overview the origin and evolution of the CCN gene family.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Kuan& Tao, Yiming& Li, Juanni& Liu, Zhuang& Zhu, Xinyan& Wang, Zhiming. 2019. A Comparative Genomic and Phylogenetic Analysis of the Origin and Evolution of the CCN Gene Family. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Kuan…[et al.]. A Comparative Genomic and Phylogenetic Analysis of the Origin and Evolution of the CCN Gene Family. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1128028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Kuan& Tao, Yiming& Li, Juanni& Liu, Zhuang& Zhu, Xinyan& Wang, Zhiming. A Comparative Genomic and Phylogenetic Analysis of the Origin and Evolution of the CCN Gene Family. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1128028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر