Characterization of Detailed Audiological Features of Cytomegalovirus Infection: A Composite Cohort Study from Groups with Distinct Demographics

المؤلفون المشاركون

Lee, Jun Ho
Oh, Seung Ha
Suh, Myung-Whan
Kim, Bong Jik
Han, Jae Joon
Shin, Seung Han
Kim, Han-Suk
Yang, Hye Ran
Choi, Eun Hwa
Chang, Mun Young
Lee, Sang-Yeon
Koo, Ja-Won
Choi, Byung Yoon

المصدر

BioMed Research International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-08-30

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Congenital cytomegalovirus (cCMV) infection is a common congenital infection that causes sensorineural hearing loss (SNHL).

Despite its substantial impact on public health and cost burden, epidemiology and clinical features of CMV-related SNHL have never been reported in the Korean populations.

This study investigated the detailed audiologic phenotypes of cCMV infection to see if a specific SNHL pattern is associated with a particular clinical setting.

A total of 38 patients with cCMV infection were studied retrospectively.

Patients were classified into three groups with distinct demographics: clinically driven diagnosis (n=17), routine newborn CMV screening according to the NICU protocols (n=10), or referral to ENT for cochlear implant (CI) (n=11).

The incidence of cCMV infection was 3.6%, showing 33.3% of SNHL among cCMV patients, 38% of asymmetric hearing loss, 29% of late-onset hearing loss, and diverse severity spectrum in patients with CMV-related SNHL.

CI recipients with CMV-related SNHL showed a significantly improved speech perception.

Surprisingly, in 36.4 % of CI implantees, initial audiological manifestation was significant asymmetry of hearing thresholds between both ears, with better ear retaining significant residual hearing up to 50dB.

CMV turns out to be a significant etiology of SNHL, first to date reported in the Korean pediatric population.

Analysis of audiologic phenotypes showed a very wide spectrum of SNHL and favorable CI outcomes in case of profound deafness.

Especially for the patients with asymmetric hearing loss, close surveillance of hearing should be warranted and CI could be considered on the worse side first, based on the observation of rapid progression to profound deafness of better side.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kim, Bong Jik& Han, Jae Joon& Shin, Seung Han& Kim, Han-Suk& Yang, Hye Ran& Choi, Eun Hwa…[et al.]. 2018. Characterization of Detailed Audiological Features of Cytomegalovirus Infection: A Composite Cohort Study from Groups with Distinct Demographics. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128257

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kim, Bong Jik…[et al.]. Characterization of Detailed Audiological Features of Cytomegalovirus Infection: A Composite Cohort Study from Groups with Distinct Demographics. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128257

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kim, Bong Jik& Han, Jae Joon& Shin, Seung Han& Kim, Han-Suk& Yang, Hye Ran& Choi, Eun Hwa…[et al.]. Characterization of Detailed Audiological Features of Cytomegalovirus Infection: A Composite Cohort Study from Groups with Distinct Demographics. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128257

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1128257