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Effect of Stains on LDL Reduction and Liver Safety: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Zhao, Qing-hua
Liang, Xiao
He, Qin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aim.
Statin is a class of medications used to decrease low-density lipoprotein cholesterol level to prevent cardiovascular disease.
However, the risk of hepatic damage caused by statin therapy is still controversial.
We conducted a systematic review and meta-analysis summarizing the existing evidence of the effect of statin therapy on incidence of liver injury to clarify whether statin therapy could lead to liver function test abnormalities.
Methods.
We searched the Cochrane Library, PubMed, and Embase database for the relevant studies update till Jan.
2017 regarding statin therapy and liver injury.
Two researchers screened the literature independently by the selection and exclusion criteria.
Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using random effects models, and subgroup analyses were performed by study characteristics.
This meta-analysis was performed by STATA 13.1 software.
Results.
Analyses were based on 74,078 individuals from 16 studies.
The summary OR of statin therapy was 1.18 (95% CI: 1.01–1.39, p=0.04; I2=0.0%) for liver injury.
Subgroup analysis indicated that fluvastatin increased the risk of liver injury significantly (OR, 3.50; 95% CI: 1.07–11.53, p=0.039; I2=0.0%) and dose over 40 mg/daily had an unfavorable effect on the liver damage (OR, 3.62; 95% CI: 1.52–8.65, p=0.004; I2=0.0%).
The sensitivity analysis indicated that the results were robust.
Conclusion.
Our findings confirm that statin therapy substantially increases the risk of liver injury, especially using fluvastatin over 40 mg/d.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Xiao& He, Qin& Zhao, Qing-hua. 2018. Effect of Stains on LDL Reduction and Liver Safety: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128260
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Xiao…[et al.]. Effect of Stains on LDL Reduction and Liver Safety: A Systematic Review and Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128260
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Xiao& He, Qin& Zhao, Qing-hua. Effect of Stains on LDL Reduction and Liver Safety: A Systematic Review and Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128260
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128260
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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