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Clinical Characteristics and Survival Outcomes for Non-Small-Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Double Mutations
المؤلفون المشاركون
Yang, Gui-Fang
Peng, Min
Weng, Yi Ming
Liu, Hua Li
Yao, Yi
Han, Guang
Song, Qi Bin
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Multiple randomized clinical trials have demonstrated that epidermal growth factor receptor (EGFR) exon 19 deletion (19Del) and exon 21 L858R mutation (L858R) are highly correlated with sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment in non-small-cell lung cancer (NSCLC).
A mutation in exon 20 (T790M) is reportedly associated with resistance to EGFR-TKIs.
However, few studies have focused on patients harboring double mutations in these 3 mutation sites.
In this retrospective study, forty-five patients (45/2546, 1.7%) harbored double mutations of 19Del, L858R, and T790M.
Twenty-four patients with EGFR double mutations received EGFR-TKI therapy.
Clinical characteristics of these patients, including the response to EGFR-TKIs and progression-free survival outcome for EGFR-TKI treatment (PFS-TKI), were analyzed.
Patients with EGFR double mutations were more likely to be nonsmokers, have an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0-1, have adenocarcinoma, and be at stage III-IV.
The ORR, DCR, and median PFS-TKI in patients harboring EGFR double mutations were lower than in patients with a single EGFR-activating mutation.
The differences in ORR and DCR were statistically insignificant between the 3 groups.
Patients with double mutations of 19Del and T790M had longer PFS-TKIs than patients in the other 2 groups.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Min& Weng, Yi Ming& Liu, Hua Li& Yang, Gui-Fang& Yao, Yi& Han, Guang…[et al.]. 2018. Clinical Characteristics and Survival Outcomes for Non-Small-Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Double Mutations. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128308
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Min…[et al.]. Clinical Characteristics and Survival Outcomes for Non-Small-Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Double Mutations. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128308
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Min& Weng, Yi Ming& Liu, Hua Li& Yang, Gui-Fang& Yao, Yi& Han, Guang…[et al.]. Clinical Characteristics and Survival Outcomes for Non-Small-Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Double Mutations. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128308
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128308
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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