α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress
المؤلفون المشاركون
Herbet, Mariola
Izdebska, Magdalena
Piątkowska-Chmiel, Iwona
Gawrońska-Grzywacz, Monika
Natorska-Chomicka, Dorota
Pawłowski, Kamil
Sysa, Marcin
Ślaska, Brygida
Dudka, Jarosław
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Chronic exposure to stress factors contributes to the development of depression by generating excess of reactive oxygen species which leads to oxidative stress and inflammatory processes.
The aim of the study was to assess the potential protective properties of α-tocopherol supplementation on the rats exposed to chronic variable stress (CVS).
Male Wistar rats (50-55 days old, weighing 200-250 g) were divided into three groups (n=10): control, stressed, and stressed and receiving (+)-α-tocopherol solution in a dose of 100 mg/kg/day.
Rats in the stressed groups were exposed to CVS for 40 days.
Markers of redox disorders (glutathione reduced and oxidized levels, GSH/GSSG ratio, glutathione peroxidase, glutathione reductase activities, total antioxidant status, and lipid peroxidation) and inflammatory response (IL-1β, IL6, and TNF-α) were determined in the blood.
Additionally, molecular biomarkers of depression (expression of Fkbp5 and Tph2) were studied in hippocampus.
The biochemical analysis was inconclusive about the presence of oxidative stress in the blood of rats exposed to CVS.
However, changes in all parameters suggest presence of redox equilibrium disorders.
Similarly, activation of inflammatory processes was observed as a result of CVS.
Molecular effects of environmental stress in hippocampus were also observed.
Generally, α-tocopherol ameliorated redox equilibrium disorders, tempered inflammatory response, and protected from changes in determined molecular markers of depression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Herbet, Mariola& Izdebska, Magdalena& Piątkowska-Chmiel, Iwona& Gawrońska-Grzywacz, Monika& Natorska-Chomicka, Dorota& Pawłowski, Kamil…[et al.]. 2018. α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128329
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Herbet, Mariola…[et al.]. α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1128329
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Herbet, Mariola& Izdebska, Magdalena& Piątkowska-Chmiel, Iwona& Gawrońska-Grzywacz, Monika& Natorska-Chomicka, Dorota& Pawłowski, Kamil…[et al.]. α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128329
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128329
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر