α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress
Joint Authors
Herbet, Mariola
Izdebska, Magdalena
Piątkowska-Chmiel, Iwona
Gawrońska-Grzywacz, Monika
Natorska-Chomicka, Dorota
Pawłowski, Kamil
Sysa, Marcin
Ślaska, Brygida
Dudka, Jarosław
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chronic exposure to stress factors contributes to the development of depression by generating excess of reactive oxygen species which leads to oxidative stress and inflammatory processes.
The aim of the study was to assess the potential protective properties of α-tocopherol supplementation on the rats exposed to chronic variable stress (CVS).
Male Wistar rats (50-55 days old, weighing 200-250 g) were divided into three groups (n=10): control, stressed, and stressed and receiving (+)-α-tocopherol solution in a dose of 100 mg/kg/day.
Rats in the stressed groups were exposed to CVS for 40 days.
Markers of redox disorders (glutathione reduced and oxidized levels, GSH/GSSG ratio, glutathione peroxidase, glutathione reductase activities, total antioxidant status, and lipid peroxidation) and inflammatory response (IL-1β, IL6, and TNF-α) were determined in the blood.
Additionally, molecular biomarkers of depression (expression of Fkbp5 and Tph2) were studied in hippocampus.
The biochemical analysis was inconclusive about the presence of oxidative stress in the blood of rats exposed to CVS.
However, changes in all parameters suggest presence of redox equilibrium disorders.
Similarly, activation of inflammatory processes was observed as a result of CVS.
Molecular effects of environmental stress in hippocampus were also observed.
Generally, α-tocopherol ameliorated redox equilibrium disorders, tempered inflammatory response, and protected from changes in determined molecular markers of depression.
American Psychological Association (APA)
Herbet, Mariola& Izdebska, Magdalena& Piątkowska-Chmiel, Iwona& Gawrońska-Grzywacz, Monika& Natorska-Chomicka, Dorota& Pawłowski, Kamil…[et al.]. 2018. α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128329
Modern Language Association (MLA)
Herbet, Mariola…[et al.]. α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1128329
American Medical Association (AMA)
Herbet, Mariola& Izdebska, Magdalena& Piątkowska-Chmiel, Iwona& Gawrońska-Grzywacz, Monika& Natorska-Chomicka, Dorota& Pawłowski, Kamil…[et al.]. α-Tocopherol Ameliorates Redox Equilibrium and Reduces Inflammatory Response Caused by Chronic Variable Stress. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1128329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128329