Effect of Repeated Injection of Iodixanol on Renal Function in Healthy Wistar Rats Using Functional MRI
المؤلفون المشاركون
Ren, Ke
Wang, Yongfang
Xie, Lizhi
Sun, Wenge
Liu, Yi
Li, Songbai
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-04
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Purpose.
To determine the optimal time interval of repeated intravenous injections of iodixanol in rat model and to identify the injury location and causes of renal damage in vivo.
Materials and Methods.
Rats were randomly divided into Control group, Group 1 with one iodixanol injection, and Group 2 with two iodixanol injections.
Group 2 was subdivided into 3 cohorts according to the interval between the first and second iodixanol injections as 1, 3, and 5 days, respectively.
Blood oxygen level-dependent (BOLD) imaging and diffusion weighted imaging (DWI) were performed at 1 hour, 1 day, 3 days, 5 days, and 10 days after the application of solutions.
Results.
Compared with Group 1 (7.2%), Group 2 produced a remarkable R2⁎ increment at the inner stripe of the renal outer medulla by 15.37% (P=0.012), 14.83% (P=0.046), and 13.53% (P>0.05), respectively, at 1 hour after repeated injection of iodixanol.
The severity of BOLD MRI to detect renal hypoxia was consistent with the expression of HIF-1α and R2⁎ was well correlated with HIF-1α expression (r=0.704).
The acute tubular injury was associated with urinary NGAL and increased significantly at 1 day.
Conclusions.
Repetitive injection of iodixanol within a short time window can induce acute kidney injury, the impact of which on renal damage in rats disappears gradually 3–5 days after the injections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yongfang& Ren, Ke& Xie, Lizhi& Sun, Wenge& Liu, Yi& Li, Songbai. 2018. Effect of Repeated Injection of Iodixanol on Renal Function in Healthy Wistar Rats Using Functional MRI. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yongfang…[et al.]. Effect of Repeated Injection of Iodixanol on Renal Function in Healthy Wistar Rats Using Functional MRI. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1128357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yongfang& Ren, Ke& Xie, Lizhi& Sun, Wenge& Liu, Yi& Li, Songbai. Effect of Repeated Injection of Iodixanol on Renal Function in Healthy Wistar Rats Using Functional MRI. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1128357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر