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The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer’s Disease
المؤلفون المشاركون
Sun, Hao-Lun
Li, Wei-Wei
Zhu, Chi
Jin, Wang-Sheng
Liu, Yu-Hui
Zeng, Fan
Wang, Yan-Jiang
Bu, Xian-Le
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Recent study shows that blood-derived amyloid-beta (Aβ) can induce cerebral amyloidosis and is involved in the pathogenesis of Alzheimer’s disease (AD).
The vast majority of blood Aβ is generated from platelet.
Whether blood Aβ levels are associated with the count of platelets remains unknown.
Methods.
58 clinically diagnosed AD patients, 18 11C-PIB-PET diagnosed AD patients, and 61 age- and gender-matched cognitively normal controls were included to analyze the correlation of plasma Aβ levels with platelet count.
13 AD patients and 40 controls with cerebrospinal fluid (CSF) samples were included to further analyze the correlation of CSF Aβ levels with platelet count.
Aβ40 and Aβ42 levels in plasma and CSF were measured by ELISA kits.
Results.
The plasma Aβ42 level was positively correlated with platelet count in both AD patients and control group, especially in AD patients with positive PIB-PET, while there was no correlation as to Aβ40.
The CSF Aβ levels also had no significant correlation with platelet count.
Conclusion.
It suggests that platelets may be involved in the pathogenesis of AD and become a potential peripheral biomarker for AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Hao-Lun& Li, Wei-Wei& Zhu, Chi& Jin, Wang-Sheng& Liu, Yu-Hui& Zeng, Fan…[et al.]. 2018. The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer’s Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128387
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Hao-Lun…[et al.]. The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer’s Disease. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128387
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Hao-Lun& Li, Wei-Wei& Zhu, Chi& Jin, Wang-Sheng& Liu, Yu-Hui& Zeng, Fan…[et al.]. The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer’s Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128387
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128387
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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